We present a case of sigmoid colon injury after blunt abdominal trauma. The patient was submitted to sigmoid resection with primary end-to-end colo-colic anastomosis. He died 22 days after operation with septic shock and acute respiratory failure. Post-mortem examination showed left lung generalized pneumonia with no signs of intra-abdominal pathology; colo-colic anastomosis was intact. We revi...

Crude incidence rates (per 105) were 181 in urban and 149 in rural (ASR: 149 in urban & 122 in rural) with 21% higher incidence (CI:1.2-1.3) and 7% mortality (CI:=1.0-1.16) and lower fatality (mortality/incidence) (38.3% urban vs. 43.0% rural) in urban. Common cancers were lung (CR: 19.2, ASR: 15.4), prostate (CR: 19.0, ASR: 15.0) and colo-rectum (CR: 15.3, ASR: 12.4) in urban and lung (CR: 21....

The prevalence of perforated sigmoid diverticular disease in developed countries increased from 2.4/100,000 in 1986, to 3.8/100,000 in 2000. [2] Approximately 50% of all people have diverticula by the time they are 50 years of age, and nearly 70% of all people have diverticula by the time they are 80 years of age. [3] Approximately 75% of people with diverticula have asymptomatic diverticulosis...

The prevalence of perforated sigmoid diverticular disease in developed countries increased from 2.4/100,000 in 1986, to 3.8/100,000 in 2000. [2] Approximately 50% of all people have diverticula by the time they are 50 years of age, and nearly 70% of all people have diverticula by the time they are 80 years of age. [3] Approximately 75% of people with diverticula have asymptomatic diverticulosis...

Colo 320 cells are colonic carcinoma cells known to express abundant c-myc mRNA. Based on the response of several hematopoietic cell lines to chemical inducers of differentiation, we reasoned that such agents might have similar inductive activity in Colo 320 cells. Accordingly, we exposed Colo 320 cells to 5 mM sodium butyrate (NaBT) for 7 d. C-myc expression decreased threefold and self-replic...

Pure olive oil triglycerides (POLO), free from all unsaponifiable matter, were isolated from Virgin Spanish olive oil (COLO) by alumina-charcoal column chromatography. COLO and POLO were used as sources of dietary fat in two animal studies. The responses of serum and liver lipids to the two types of dietary fat were examined. Our results show that animals fed POLO-diet gave somewhat higher seru...

Just to sit in this dark place, and magic takes place on the wall. For a moment, we forgot apartheid, we forgot there was another world that wasn’t good; we sat there, and were carried away by the dream of these American movies. Actor John Kani to Peter Davis 1990, 23 On January 25, 1959, a short but rather glowing review appeared in The Golden City Post, one of South Africa’s most popular news...

BACKGROUND Interleukin-22 (IL-22) plays a prominent role in epithelial regeneration and dampening of chronic inflammatory responses by protecting intestinal stem cells from immune-mediated tissue damage. IL-22 has a considerable therapeutic potential in graft-versus-host disease (GVHD), which is a frequent and challenging complication following allogeneic stem cell transplantation. The aim of o...

Detergent-soluble membrane vesicles are actively released by human pancreas (Colo-/Colo+) and colon (CX-/CX+) carcinoma sublines, differing in their capacity to present heat shock protein 70 (Hsp70)/Bag-4 on their plasma membranes. Floating properties, acetylcholine esterase activity, and protein composition characterized them as exosomes. An enrichment of Rab-4 documented their intracellular t...

BACKGROUND After total mesorectal excision for rectal cancer, many surgeons try to avoid an abdominoperineal resection (APR) by performing a transanally double stapled low colo-rectal anastomosis (LRA), frequently without a pouch. This policy is mainly based on the assumption that the quality of life after such LRA is higher than after APR. It has been suggested that a better functional outcome...