Coccidioidomycosis was first described in Argentina in 1892 by Alexandro Posadas (4). Robert Wernecke confirmed the syndrome in the same year and, together with Posadas, discerned that the etiologic agent was infectious. Rixford and Gilchrist formally described the organism in California, and thinking the organism to be a coccidian protozoan, they named it Coccidioides immitis Rixford and Gilch...

C-ASWS-M, the alkali-soluble, water-soluble cell wall antigen of Coccidioides immitis mycelia, was evaluated for its vaccine potential in mice. Vaccination with 0.5-, 1.5-, or 3-mg doses of C-ASWS-M in complete Freund adjuvant provided a significant level of protection against intraperitoneal challenge with 1,500 arthroconidia (P < 0.0001 with each dose). Vaccination with 1 mg of C-ASWS-M prote...