Surface tension and dilational viscoelasticity of solutions of various surfactants measured with bubble and drop profile analysis tensiometry are discussed. The study also includes experiments on the co-adsorption of surfactant molecules from a solution drop and alkane molecules from saturated alkane vapor phase. Using experimental data for 12 surfactants with different surface activities, it i...

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The present work was aimed to develop and characterize rosuvastatin loaded self emulsifying drug delivery system for the effective management of hypolipidemia (RSEDDS) for improving bioavailability, to enhance solubility, to prolong residence time and to provide sufficient amount of drug to a target site in a sustained release manner. Self-emulsifying drug delivery system was prepared by simple...

In earlier inhalation exposures of rabbits, nickel increased the production of surfactant by type II cells, with secondary effects on morphology and function of alveolar macrophages. Cobalt induced mainly a nodular growth pattern of the type II cells. Trivalent chromium seemed to impair the capacity of macrophages to catabolize surfactant but did not affect the type II cells. We exposed rabbits...

Cobalt oxide (Co3O4) nanorods were prepared by a simple co-precipitation method using ethanol solution of cobalt nitrate as precursor and cetyl trimethylammonium bromide (CTAB) as surfactant. Morphological properties of the nanoparticles were characterized. XRD measurement exhibited the structure of Co3O4 nanocrystals for annealed samples. The SEM ima...

The purpose of this study was to determine the acid dissociation constants (pKa) of meloxicam in the presence of various surfactants including sodium lauryl sulfate (SLS) as an anionic surfactant, cetyltrimethylammonium bromide (CTAB) as a cationic surfactant and Triton® TX-100 (TX-100) as a non-ionic surfactant in different pre-determined concentrations. The related pKa was determined spec...

Gallium extraction from Jajarm Bayer process liquor (Jajarm, Iran) was investigated using microemulsions. Also the behavior of aluminum was studied as an impurity. Kelex100 (4-ethyl, 1-methyl, 7-octyl, 8hydroxyquinoleine), iso-decanol and n-butanol, and kerosene were used as the surfactant, co-surfactant, and oil phase, respectively. Ternary phase diagrams were produced using various co-surfact...

Abstract Background Pemigatinib is a small molecule tyrosine kinase inhibitor of fibroblast growth factor receptor inhibitors. The oral bioavailability constricted due to its limited solubility at physiological pH. It essential develop novel formulation improve the intrinsic and reduce pharmacokinetic variability. Self-nanoemulsifying drug delivery system an effective, smart more adequate appro...

Objective: This study aimed to find the best SNEDDS meloxicam formula and analyze release kinetics of non-SNEDDS using DDSolver. 
 Methods: Meloxicam was prepared sunflower seed oil, Cremophor RH 40 as a surfactant, polyethylene glycol (PEG) 400 co-surfactant. Results: The obtained subjected in vitro dissolution analyzed shows one selected consists 10% 70% cremophor 40, 20% PEG with 20.5 n...

Nanoemulsion is a unique and versatile fluid that solubilizes both ionic non-ionic molecules. It has been used extensively for drug delivery. Nanoemulsion, prepared with water-oil-surfactant co-surfactant, fluorescent at or the near IR region of electromagnetic spectrum. However, when protoporphyrin (PPIX), useful photosensitizer in PDT modality, poorly water-soluble compound, introduced into n...