Cupriavidus sp. strain CNP-8 isolated from a pesticide-contaminated soil was able to utilize 2-chloro-4-nitrophenol (2C4NP) as a sole source of carbon, nitrogen and energy, together with the release of nitrite and chloride ions. It could degrade 2C4NP at temperatures from 20 to 40 °C and at pH values from 5 to 10, and degrade 2C4NP as high as 1.6 mM. Kinetics assay showed that biodegradation of...

2',3'-Cyclic nucleotide-3'-phosphodiesterase (CNP1 and CNP2 with Mr of 46,000 and 48,000, respectively) is the major enzyme of central nervous system myelin. It is associated with oligodendroglial plasma membrane and uncompacted myelin (myelin-like fraction), which are in contact with glial cytoplasm. Proteins of the myelin-like fraction were labeled with [3H]palmitic acid in brain slices from ...

BACKGROUND Community Networks Program (CNP) centers are required to use a community-based participatory research (CBPR) approach within their specific priority communities. Not all communities are the same and unique contextual factors and collaborators' priorities shape each CBPR partnership. There are also established CBPR and community engagement (CE) principles shown to lead to quality CBPR...

Rose, R. A., A. E. Lomax, and W. R. Giles. Inhibition of L-type Ca2 current by C-type natriuretic peptide in bullfrog atrial myocytes: an NPR-C-mediated effect. Am J Physiol Heart Circ Physiol 285: H2454–H2462, 2003. First published July 24, 2003; 10.1152/ajpheart.00388.2003.—Single atrial myocytes were isolated from the bullfrog heart and studied under current and voltage clamp conditions to d...

Animal studies have demonstrated that CNP causes endothelium-independent vasodilation, which is limited by neutral endopeptidase (NEP) activity. However, the vasodilating mechanism of CNP in humans is still unknown. Therefore, we investigated the vasodilator actions of CNP in human forearm resistance vessels before and after inhibition of nitric oxide (NO) and then prostacyclin production and a...

INTRODUCTION The present study examined the effect of C-type natriuretic peptide (CNP) on the anabolic and catabolic activities in chondrocyte/agarose constructs subjected to dynamic compression. METHODS Constructs were cultured under free-swelling conditions or subjected to dynamic compression with low (0.1 to 100 pM) or high concentrations (1 to 1,000 nM) of CNP, interleukin-1β (IL-1β), and...

Single atrial myocytes were isolated from the bullfrog heart and studied under current and voltage clamp conditions to determine the electrophysiological effects of the C-type natriuretic peptide (CNP). CNP (10(-8) M) significantly shortened the action potential and reduced its peak amplitude after the application of isoproteronol (10(-7) M). In voltage clamp studies, CNP inhibited isoproterono...

C-type natriuretic peptide (CNP) is a member of the natriuretic peptide family mainly distributed in the central nervous system. CNP is also produced and secreted by the endothelium and inhibits vascular smooth muscle cell proliferation. We have reported that endothelial damage stimulates only transiently vascular smooth muscle cell proliferation in arteries due to the development of an autocri...

Aim - an analysis of levels steroid hormones in heart cell mitochondria at the stages B16/F10 melanoma development combination with chronic neurogenic pain male and female C57BL/6 mice. The study included mice (n=336). Experimental groups were: intact animals (♂ n=21; ♀ n=21); controls n=21) a model (CNP); comparison group n=63; n=63) melanomas (B16/ F10); main (CNP+B16/F10) transplanted 3 week...

Understanding and controlling the performance of ceria nanoparticle (CNP) catalysts requires knowledge of the detailed structure and property of CNP surfaces and any attached functional groups. Here we report thermogravimetric analysis results showing that hydrothermally synthesized ∼30 nm CNPs are decorated with 12.9 hydroxyl groups per nm(2) of CNP surface. Quantum mechanical calculations of ...