Five-axis computer numerical control (CNC) machine tools (three linear and two rotary axes) are ideally suited to the fabrication of complex work pieces, such as dies, turbo blades, and cams. The locations of the axis average line and centerline of the rotary axes strongly influence the performance of these machines; however, techniques to compensate for eccentric error in the rotary axes remai...

The computer industry is at a major inflection point in its hardware roadmap due to the end of a decades-long trend of exponentially increasing clock frequencies. Instead, future computer systems are expected to be built using homogeneous and heterogeneous many-core processors with 10’s to 100’s of cores per chip, and complex hardware designs to address the challenges of concurrency, energy eff...

A novel quality-of-service (QoS)-aware routing scheme is proposed to support heterogeneous layered unicast transmissions and improve the wireless channel utilization through cooperative network coding (CNC) in lossy wireless mesh networks. The proposed routing scheme consists of two steps. In the first step, the scheme uses an optimization formulation to compute the optimal routes of all layere...

The mammalian Nrf/CNC proteins (Nrf1, Nrf2, Nrf3, p45 NF-E2) perform a wide range of cellular protective and maintenance functions. The most thoroughly described of these proteins, Nrf2, is best known as a regulator of antioxidant and xenobiotic defense, but more recently has been implicated in additional functions that include proteostasis and metabolic regulation. In the nematode Caenorhabdit...

The amplification of telomerase component (TERC) gene could play an important role in generation and treatment of haematological malignancies. This present study was aimed to investigate copy number amplification status of TERC gene in chronic myeloid leukaemia (CML) patients who were being treated with imatinib mesylate (IM). Genomic DNA was extracted from peripheral blood of CML-IM Resistant ...

The paper deals with the problems of trajectory building during laser computer numerical control (CNC) processing and presents a new approach to the optimization of the CNC tool trajectory during laser treatment of irregular shapes. The development of the firmware of the CNC machines encounters a number of problems, the most important of which is minimization of the processing time. Two main me...

BACKGROUND VICKZ (IGF2BP1,2,3/ZBP1/Vg1RBP/IMP1,2,3) proteins bind RNA and help regulate many RNA-mediated processes. In the midbrain region of early chick embryos, VICKZ is expressed in the neural folds and along the basal surface of the neural epithelium, but, upon neural tube closure, is down-regulated in prospective cranial neural crest (CNC) cells, concomitant with their emigration and epit...

We introduce the Concurrent Collections (CnC) programming model. In this model, programs are written in terms of high-level operations. These operations are partially ordered according to only their semantic constraints. These partial orderings correspond to data dependences and control dependences. The role of the domain expert, whose interest and expertise is in the application domain, and th...

A brick-and-mortar-like ultrasoft nanocomposite metallogel is formed by crosslinking cellulose nanocrystals (CNC) with ammonium zirconium carbonate (AZC) to trap and reconfigure dextran, a model biomacromolecule. The bricks (CNC) reinforce the metallogel, compete with dextran in reacting with AZC, and decouple long-time dextran dynamics from network formation, while the mortar (AZC) imparts bim...