BACKGROUND Human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) is a major public health problem in sub-saharan Africa. Cytomegalovirus (CMV) has been reported to enhance HIV replication and accelerate the progression of HIV infection to AIDS. OBJECTIVE This study reports on the high seropositivity of immunoglobulin (Ig) G and M antibodies against CMV and the risk factor...

The objective was to compare the use of the polymerase chain reaction (PCR), virus culture, and immunostaining of alveolar cells used alone and in combination as diagnostic methods for the rapid diagnosis of cytomegalovirus (CMV) pneumonia in marrow transplant recipients. Seventy-five marrow transplant recipients with clinical and radiological evidence of pneumonitis were used as subjects. Bron...

Over 90% of the world's population acquires a cytomegalovirus (CMV) infection. This infection, although asymptomatic or self-limiting, is a major burden to the immune system. For this reason, and because CMV immunization is possible, determining whether CMV can cause reduced longevity, particularly among those with coronary artery disease, is important and previous reports have been conflicting...

Infection by human cytomegalovirus (CMV) elicits a strong humoral immune response and robust anti-CMV antibody production. Diagnosis of virus infection can be carried out by using a variety of serological assays; however, quantification of serum antibodies against CMV may not present an accurate measure of a patient's ability to control a virus infection. CMV strains that express green fluoresc...

Vol. 203, No. 13, December 25, 2006 2865–2877 www.jem.org/cgi/doi/10.1084/jem.20052246 2865 Human CMV is a β herpes virus that establishes lifelong infection. Endothelial, renal epithelial, and pulmonary tissue as well as myeloid cells all contain latent CMV. Seroprevalence increases with age and reaches 30–70% in developed countries (1). Although serious disease can occur, it is rare. In most ...

BACKGROUND Restenosis is a common problem after all revascularization procedures in atherosclerotic coronary arteries. Reactivated human cytomegalovirus (CMV) has been detected in tissues of restenotic vascular lesions and was hypothesized to be a contributing pathogenic factor. Recent data suggest an association of restenosis after optimal coronary atherectomy with CMV serostatus, and a possib...

Prof. R. Sinniah, Department of Pathology, National University of Singapore, National University Hospital, Lower Kent Ridge Road, Singapore 0511 (Singapore) Dear Sir, Cytomegalovirus (CMV) infection is known to pursue an aggressive clinical course in patients with renal allo-grafts. In addition tubulointerstitial disease and glomer-ulopathy have been well described. However, more recently atten...

introduction : human cytomegalovirus (hcmv) is able to go into latency and is the most common cause of congenital infections in humans. its clinical manifestations range from asymptomatic forms to severe fetal damage, and in rare cases, fetal death due to abortion. this prospective cross-sectional study was designed to determine the seroprevalence of hcmv infection in pregnant women attending a...

Maternal antibodies against cytomegalovirus (CMV) infection offer, to some extent, protection against congenital CMV infection. This study describes the seroprevalence of CMV-specific IgG in 220 parturient women during pregnancy, at delivery, at 3 months after delivery and in their cord blood (Flanders, Belgium, 2006-2008). ELISA was used to measure IgG. Of this population, 30% had positive IgG...

Strategies for preventing posttransfusion CMV infections include testing for CMV antibodies, CMV DNA, and/or WBC reduction of blood components. 1,2 Early studies with molecular methods produced conflicting results. Nevertheless, recent investigations show that improved CMV PCR assays do not necessarily increase detection of CMV DNA in healthy CMV-seronegative blood donors. 3,4 We confirm these ...