In this paper, the classic job shop scheduling problem of minimizing makespan, J//Cmax, is studied. A heuristic approach is presented for solving the J//Lmax problem using an iterative deterministic simulation technique combined with simulated annealing. A simple transformation is provided for converting a J//Cmax problem to an equivalent J//Lmax problem. The approach is tested on some well-kno...

In this crossover study in 12 healthy volunteers, coadministration of amprenavir (1,200 mg; single dose) with grapefruit juice slightly reduced the maximum concentration of drug in serum (Cmax) compared to administration with water (7.11 versus 9.10 microg/ml), slightly increased the time to Cmax (1.13 versus 0.75 h), and did not affect the area under the concentration-time curve from 0 to 12 h...

The bioavailability of a generic diclofenac sodium sustained release tablet preparation (Zolterol, SR) was compared with the innovator product, Voltaren, SR. Twelve healthy adult male volunteers participated in the study, which was conducted according to a randomized, two-way crossover design with a wash out period of one week. The bioavailability of diclofenac was compared using the parameters...

This work deals with the problem of scheduling n independent jobs on m unrelated parallel machines with the objective of minimizing the makespan (the total elapsed time from the start of execution until all jobs have been completed). Preemption is not allowed. This way a job, once assigned to a particular machine, may not be removed until it has finished its execution. All the machines start wo...

A high-pressure liquid chromatographic assay was developed for the detection of HR 810 in rabbit plasma. There was no interference in the high-pressure liquid chromatographic assay from other antibiotics. The method was accurate, reproducible, and capable of detecting less than 1 microgram of HR 810 per ml in plasma. The assay correlated with the microbiological assay (correlation coefficient, ...

Scheduling concerns the allocation of limited resources overtime to perform tasks fulfill certain criterion and optimize one or several objective functions. One most popular models in scheduling theory is that flow-shop scheduling. During last 40 years, permutation sequencing problem with makespan minimization has held attraction many researchers. This characterized as Fm/prmu/Cmax notation Gra...

Background: Fascia Iliaca Compartment Block (FICB) is commonly used in older patients to provide effective analgesia following hip fracture.  Objectives: However, only limited Pharmacokinetic (PK) data about levobupivacaine are available to help clinical practice and establish safe volumes and amounts of local anesthetics. Methods: Ten patients aged between 53 and 87 years, who underwent hemi...

Introduction and Aim: We examined the effect of pre- and/or post-infection doxycycline on human nasal epithelial cell viability SARS-CoV-2 (clinical strain IHUMI-3) replication in vitro. Materials Methods: Human cells, an vivo target, were derived from healthy donor stem/progenitor cells via vitro differentiation. The exposed to at 0, 0.1, 0.5, 1, 5, 10, 50, 100 ?M before after IHUMI-3 inoculat...

A new tablet system was examined for an intestinal delivery using hydroxypropyl methylcellulose (HPMC) and shellac. HPMC incorporated into the inside of tablet, shellac coated on surface, which evaluated its controlled-release property through several dissolution tests, firstly in vitro then via two kinds clinical studies with healthy volunteers. The were originally designed by employing X-ray ...

Abstract Panobinostat is an HDAC inhibitor with dose-dependent pre-clinical activity against pediatric glioma. Reported pharmacokinetic (PK) profiles of panobinostat, including CSF penetration, have varied. We hypothesized that this variability resulted from the utilization differing panobinostat formulations. For comparison to USP grade powdered formulation PK profile formerly reported (Rodger...