نتایج جستجو برای: clozapine

تعداد نتایج: 3536  

2006
P. Turton W. Badenhorst

blood dyscrasia Dunk et al (2006) investigated 53 patients who were rechallenged with clozapine following leucopenia or neutropenia during previous therapy and found that 33 did not experience a second episode of blood dyscrasia and were able to continue drug treatment. This result is of considerable clinical relevance because it suggests that some patients with leucopenia or neutropenia may un...

2016
Susan L. Rossell Paul S. Francis Cherrie Galletly Anthony Harris Dan Siskind Michael Berk Kiymet Bozaoglu Frances Dark Olivia Dean Dennis Liu Denny Meyer Erica Neill Andrea Phillipou Jerome Sarris David J. Castle

BACKGROUND Clozapine is an effective treatment for a proportion of people with schizophrenia (SZ) who are resistant to the beneficial effects of other antipsychotic drugs. However, anything from 40-60 % of people on clozapine experience residual symptoms even on adequate doses of the medication, and thus could be considered 'clozapine resistant'. Agents that could work alongside clozapine to im...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2003
W W Blessing B Seaman N P Pedersen Y Ootsuka

Life-threatening hyperthermia occurs in some individuals taking 3,4-methylenedioxymethamphetamine (MDMA, ecstasy). In rabbits, sympathetically mediated vasoconstriction in heat-exchanging cutaneous beds (ear pinnae) contributes to MDMA-elicited hyperthermia. We investigated whether MDMA-elicited cutaneous vasoconstriction and hyperthermia are reversed by clozapine and olanzapine, atypical antip...

Journal: :Pharmacology, biochemistry, and behavior 2009
Changjiu Zhao Ming Li

Many antipsychotic drugs disrupt active components of maternal behavior such as pup approach, pup retrieval and nest building at clinically relevant doses in postpartum female rats. However, the neurochemical mechanisms underlying such a disruptive effect remain to be determined. This study examined the neurochemical mechanisms that mediate the disruptive effects of haloperidol (a typical antip...

2008
Ricardo de Oliveira-Souza Rogério Paysano Marrocos Jorge Moll

Clozapine has become a keystone in the treatment of schizophrenia because of its efficacy as an antipsychotic with negligible neuroleptic effects. The long-term stability of its effects, however, is poorly understood, because most studies have probed the usefulness of clozapine over a period of weeks to several months at the most. Knowing whether clozapine's benefits are sustained over the very...

Journal: :The Journal of pharmacology and experimental therapeutics 1997
A H Tang S R Franklin C S Himes M W Smith R E Tenbrink

The atypical antipsychotic drug clozapine interacts with multiple transmitter systems, among them the D4 subtype of dopamine receptors. PNU-96415E is chemically unrelated to clozapine and has its highest binding affinity for the D4 and 5-HT2A receptors. In comparison to clozapine, PNU-96415E is weaker in binding to D1, D2, alpha1 and muscarinic receptors. PNU-96415E inhibited exploratory locomo...

Journal: :Chang Gung medical journal 2012
Chung-Huei Huang Shin-Huei Fu Samuel Hsu Yu-Yao Huang Szu-Tah Chen Brend Ray-Sea Hsu

BACKGROUND Clozapine, an atypical antipsychotic drug, induces derangements in glucose homeostasis in certain patients. This study investigated the mechanisms of clozapine-induced beta-cell toxicity. METHODS Fifty-two healthy C57BL/6 male mice were randomized into 4 groups to study the effects of clozapine (group C, D) and a high-fat diet (group B, D). Three mice from each group were randomly ...

Journal: :Revista brasileira de psiquiatria 2015
Giovana J Garcia Marcos H Chagas Carlos H Silva João P Machado-de-Sousa José A Crippa Jaime E Hallak

OBJECTIVE Schizophrenia is one of the most severe psychiatric disorders, and its current treatment relies on antipsychotic medications with only partial effectiveness. Clozapine is an atypical antipsychotic with a specific profile of action indicated for treatment-resistant schizophrenia. Neuroimaging studies assessing the effects of clozapine could help shed light on the neural underpinnings o...

2015
Ippei Takeuchi Tatsuyo Suzuki Taro Kishi Daisuke Kanamori Manako Hanya Junji Uno Kiyoshi Fujita Hiroyuki Kamei

Clozapine has been demonstrated to be useful for treating refractory schizophrenia. However, hypersalivation occurs in 31.0- 97.4% of the patients treated with clozapine. Accordingly, some patients who are disturbed by their hypersalivation refuse to continue with clozapine treatment. This study investigated the efficacy of the anticholinergic agent scopolamine butylbromide against clozapine-in...

Journal: :Middle East Current Psychiatry 2023

Abstract Background Clozapine is a second-generation antipsychotic which known to have superior efficacy as compared other antipsychotics. It particularly used in treatment-resistant schizophrenia (10–30%). However, its use limited due the serious side effect of inducing seizures can occur at all doses. The purpose our study was analyse patients taking clozapine for any electroencephalographic ...

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