The peripheral and central neural actions of clonidine on normal and glaucomatous eyes have been investigated. Threshold doses of clonidine applied topically induced a monotonic decrease of intraocular pressure in the treated eye and had no effect on the contralateral eye. With increased clonidine dose, a decrease of intraocular pressure occurred in the untreated eye, and there was a concomitan...

Implication for health policy/practice/research/medical education: Clonidine, a relatively old anti-hypertensive agent, has been used during the last years, as an analgesic agent. Nowadays, this drug has been used not only orally, but also, intravenously and interathechally; which possibly suggest newer mechanisms. There are emerging evidence for this fact. Copyright © 2011, ISRAPM, Published b...

In this study, the effect of α-adrenoceptor agents on imipramine-induced antinociception was investigated using formalin test. Intraperitoneal (i.p.) administration of imipramine at different doses (10-80 mg/kg) induced antinociception in both phases of formalin test. In addition, intracerebroventricular (i.c.v.) injection of imipramine (1, 5, and 10 µg/rat) did not elicit any effect, although ...

INTRODUCTION Recent studies (Gold et al, 1978; Washton et al, 1980a) showing that the non-opiate antihypertensive agent, clonidine hydrochloride, suppresses signs and symptoms of opiate withdrawal, have suggested that clonidine and similar drugs might be useful in the clinical management of opiate detoxification. The fact that clonidine is not an opiate drug and does not itself produce addictio...

UNLABELLED On the basis of the determination of minimum local analgesic concentration (MLAC), ropivacaine has been demonstrated to be less potent than bupivacaine during the first stage of labor. In this study we assessed the effect of clonidine on the MLAC of ropivacaine. Seventy-seven parturients of mixed parity requesting epidural analgesia for labor (cervical dilation, 3-7 cm) were included...

Effects of intracerebroventricular (i.c.v.) treatment with atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) on the pressor response to i.c.v.-injected clonidine were investigated in conscious rats. I.c.v.-pretreatment with ANP (10 micrograms) or BNP (10 micrograms) inhibited the pressor response to i.c.v.-injected clonidine (10 micrograms). Systemic (i.v.) treatment with ANP...

Large doses of the imidazoline alpha 2 adrenoreceptor agonist clonidine aggravate ethanol-induced gastric lesions. The alpha 2 adrenoceptor antagonist phentolamine, the opioid antagonist naloxone and the H2 antagonist cimetidine do not prevent this action of clonidine suggesting that it is not mediated by alpha 2, opioid or H2 receptors. Further, like clonidine, high doses of phentolamine and c...

Postoperative analgesia for inguinal hernia procedures can be provided safely and effectively with USG guided TAP blocks. In the block following repair, we compared analgesic effectiveness of dexmedetomidine clonidine. : Seventy four patients undergoing repair under spinal anesthesia were randomly divided in to Group LD (n=37) LC (n=37). Patients received a unilateral USG-guided 0.5% levobupiva...

Background: Caudal block is a common technique for paediatric analgesia but has disadvantage of short duration of action after single injection. Various adjuvants were tried with local anaesthetics to prolong duration of post-operative analgesia in caudal block. This prospective study was designed to assess and compare the efficacy of clonidine and dexmedetomidine used as adjuvants to bupivacai...