Under climate change, river ecological base flow becomes particularly critical for the health and stability of inland ecosystems in arid regions. Taking three typical seasonal rivers, including Kriya River, Niya Qarqan all on northern slope Kunlun Mountains, as research objects, meteorological data from 1958 to 2019 hydrological 1978 2014 were selected analyze characteristics under change. The ...

The reaction of 1 H -benzoimidazole-2-carbaldehyde with 4-oxo-2-thioxothiazolidin-3-ylcarboxilic acids was studied and the combinatorial library 5-(1 -benzoimidazol-2-ylmethylene)-4-oxo-2-thioxothiazolidin-3-ylcarboxilic has been prepared. structures target compounds 8a-f , 9 10a, b were confirmed by using NMR spectroscopy elemental analysis. synthesized selected National Cancer Institute (NCI)...

Abstract Previous studies show that the environment in Guangdong, Hong Kong, and Macao region is under double stress of global warming urbanization. Here, we due to increase regional greenness, effect urbanization on surface air temperature (SAT) decreased with time became statistically insignificant from 2004 2018, compared 1979 onward; while itself has significantly warmed land (LST), a rate ...

A series of high-density polyethylene/Cloisite 20A/graphite nanocomposites were prepared via melt blending for the production of polymeric pipes for natural gas transfer. The microstructural, mechanical, thermal, electrical and barrier properties of prepared nanocomposites were investigated. An intercalated morphology was observed for prepared nanocomposites. Improved mechanical properties ...

A series of new derivatives (5-29) of marine-derived bostrycin (1) were synthesized. The in vitro cytotoxic activities of all compounds were evaluated against MCF-7, MDA-MB-435, A549, HepG2, HCT-116 and MCF-10A cells using the MTT method. The compounds 7, 8, 22, 23, 25, 28 and 29 of the total showed comparable activity to epirubicin, the positive control, against the tested cancer cell lines. H...

This paper describes an antibody (mAb 7D6) that specifically recognizes human follicular dendritic cells (FDCs). By expression cloning, a cDNA clone encoding for the long human CR2/ CD21 isoform (CD21L) that contains an additional exon (10a) was isolated. We demonstrated that FDCs selectively express CD21L, while B cells selectively express the short CR2/CD21 lacking exon 10a (CD21S). By screen...

The oxidative cyclisation of a range of benzothieno[2,3-d]pyrimidine hydrazones (7a-e) to the 1,2,4-triazolo[4,3-c]pyrimidines (8a-e) catalysed by lithium iodide or to the 1,2,4-triazolo[1,5-c]pyrimidines (10a-e) with sodium carbonate is presented. A complementary synthesis of the 1,2,4-triazolo[1,5-c]pyrimidines (10a-e) starting from the amino imine 11 is also reported. The effect of these com...

Protein tyrosine phosphatase 1B (PTP1B) is a key negative regulator of insulin signaling pathway. Inhibition of PTP1B is expected to improve insulin action. Appropriate selectivity and permeability are the gold standard for excellent PTP1B inhibitors. In this work, molecular hybridization-based screening identified a selective competitive PTP1B inhibitor. Compound 10a has IC50 values of 199 nM ...

The carbene adducts 3a-c (R 1 = Me, Et, iso-Pr; R2 = Me) are formed from the 2,3-dihydroimidazol-2-ylidenes la-c and 1,2-dichloroethane as air-sensitive solids in good yields. The compounds exhibit a reactive Cl-Cl bond. Benzene is chlorinated by 3a,b to give chlorobenzene and the imidazolium salts 10a,b under mild conditions. 3c acts as a chloride donor to give with AICI3 and S 0 2 the 2-chlor...