نتایج جستجو برای: clinical trial committee

تعداد نتایج: 1404691  

2000
Frank Cowell Maria-Pia Victoria-Feser

We show how a collection of results in the literature on the empirical estimation of welfare indicators from sample data can be unified. We also demonstrate how some of these ideas can be extended to empirically important cases where the data have been trimmed or censored.

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Journal: :Journal of family issues 2013
Alfred Demaris

This study examines several aspects of the association between engaging in extramarital sex and the disruption of one's marriage. In particular: is there a differential effect on disruption depending on the gender of the perpetrator? Is the effect of infidelity primarily due to its negative impact on marital quality and one's resistance to divorce? Are there characteristics of marriages that co...

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2011
Ngozi Ejiogu Jennifer H. Norbeck Marc A. Mason Bridget C. Cromwell Alan B. Zonderman Michele K. Evans

PURPOSE OF THE STUDY Investigating health disparities requires studies designed to recruit and retain racially and socioeconomically diverse cohorts. It is critical to address the barriers that disproportionately affect participation in clinical research by minorities and the socioeconomically disadvantaged. This study sought to identify and rectify these barriers to recruit and retain a biraci...

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Journal: :Statistics in medicine 2004
Scarlett L Bellamy Yi Li Louise M Ryan Stuart Lipsitz Marina J Canner Rosalind Wright

Many authors in recent years have proposed extensions of familiar survival analysis methodologies to apply in dependent data settings, for example, when data are clustered or subject to repeated measures. However, these extensions have been considered largely in the context of right censored data. In this paper, we discuss a parametric frailty model for the analysis of clustered and interval ce...

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Journal: :Risk analysis : an official publication of the Society for Risk Analysis 2015
Louis J M Aslett Frank P A Coolen Simon P Wilson

The concept of survival signature has recently been introduced as an alternative to the signature for reliability quantification of systems. While these two concepts are closely related for systems consisting of a single type of component, the survival signature is also suitable for systems with multiple types of component, which is not the case for the signature. This also enables the use of t...

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Journal: :Canadian Respiratory Journal 2003

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2015
Nicola L. Harman Elizabeth J. Conroy Steff C. Lewis Gordon Murray John Norrie Matt R. Sydes J. Athene Lane Douglas G. Altman Colin Baigent Judith M. Bliss Marion K. Campbell Diana Elbourne Stephen Evans Peter Sandercock Carrol Gamble

BACKGROUND The independent oversight of clinical trials, which is recommended by the Medical Research Council (MRC) Guidelines for Good Clinical Practice, is typically provided by an independent advisory Data Monitoring Committee (DMC) and an independent executive committee, to whom the DMC makes recommendations. The detailed roles and function of this executive committee, known as the Trial St...

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Journal: :Gut 1997
M J Farthing R G Newcombe

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Journal: :Biometrical journal. Biometrische Zeitschrift 2011
Roger Koenker

The Laplace likelihood method for estimating linear conditional quantile functions with right censored data proposed by Bottai and Zhang (2010) is demonstrated to be highly non-robust.

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Journal: :Annals of statistics 2003
Mark J VAN DER Laan Nicholas P Jewell

We study nonparametric estimation with two types of data structures. In the first data structure n i.i.d. copies of (C, N(C)) are observed, where N is a finite state counting process jumping at time-variables of interest and C a random monitoring time. In the second data structure n i.i.d. copies of (C ∧ T, I (T ≤ C), N(C ∧ T)) are observed, where N is a counting process with a final jump at ti...

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