نتایج جستجو برای: clinical trial
تعداد نتایج: 1365604 فیلتر نتایج به سال:
In his discussion of Cox's (1972) paper on proportional hazards regression, Breslow (1972) provided the maximum likelihood estimator for the cumulative baseline hazard function. This estimator is commonly used in practice. The estimator has also been highly valuable in the further development of Cox regression and semiparametric inference with censored data. The present paper describes the Bres...
The package icenReg provides classic survival regression models for interval-censored data. We present an update to the package that extends the parametric models into the Bayesian framework. Core additions include functionality to define the regression model with the standard regression syntax while providing a custom prior function. Several other utility functions are presented that allow for...
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We consider longitudinal clinical data for HIV patients undergoing treatment interruptions. We use a nonlinear dynamical mathematical model in attempts to fit individual patient data. A statistically-based censored data method is combined with inverse problem techniques to estimate dynamic parameters. The predictive capabilities of this approach are demonstrated by comparing simulations based o...
BACKGROUND Recent evidence has highlighted deficiencies in clinical trial protocols, having implications for many groups. Existing guidelines for randomized clinical trial (RCT) protocol content vary substantially and most do not describe systematic methodology for their development. As one of three prespecified steps for the systematic development of a guideline for trial protocol content, the...
background and objectives : examination of cartilage repair in animal work is dependent upon the thickness and radius of the induced impalement. full-thickness defects with a radius of 3 mm have been commonly used in animal studies to evaluate new procedures designed to improve the quality of articular cartilage repair. the aim of the present study was to define the biomechanical characteristi...
Background: Wart is a common skin disease that can occur at any age. While they are usually benign and self-limited, they can become irritating and cosmetically disabling to patients. The objective of this study is to compare the effectiveness of a topical 85% formic acid preparation with a combination of topical salicylic acid and lactic acid.Methods: We enrolled 66 pa...
Background and objectives: Optimal surgical management of the neonate with imperforate anus (IA) depends on determining accurate location of muscle complex, pouch of rectum and urethral fistula. The aim of this study was to investigate a novel minimally invasive technique of anorectoplasty assisted by intraoperative sonography pull-through for repair of anorectal malformation and rectourinary f...
Background Late onset sepsis is a frequent complication of prematurity, associated with increased mortality and morbidity. Probiotics may prevent late onset sepsis in premature infants. The aim of this study was to determine prophylactic effect of oral probiotics in prevention of late onset sepsis of very preterm infants. Materials and Methods This study was a randomized, double blinded, placeb...
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