Up to 50% of patients with uveal melanoma develop metastatic disease with poor prognosis. Regional, mainly liver-directed, therapies may induce limited tumor responses but do not improve overall survival. Response rates of metastatic uveal melanoma (MUM) to systemic chemotherapy are poor. Insights into the molecular biology of MUM recently led to investigation of new drugs. In this study, to co...

Informed consent is increasingly heralded as an ethical panacea, a tool to counter autocratic and paternalistic medical practices. Debate about the implementation of informed consent is constricted and polarised, centring on the right of individuals to be fully informed and to freely choose versus an autocratic, paternalistic practice that negates individual choice. A bioethical framework, base...

This article develops a method to estimate the impact of change in a particular social setting, the residential neighborhood, that is designed to address nonrandom selection into a neighborhood and nonrandom selection out of a neighborhood. Utilizing matching to confront selection into neighborhood environments and instrumental variables to confront selection out of changing neighborhoods, the ...

ackground: When individual judgment conflicts with a group, the individual will often conform his judgment to that of the group. onformity might arise at an executive level of decision making, or it might arise because the social setting alters the individual’s erception of the world. ethods: We used functional magnetic resonance imaging and a task of mental rotation in the context of peer pres...

OBJECTIVES To study sensor monitoring (use of a sensor network placed in the home environment to observe individuals' daily functioning (activities of daily living and instrumental activities of daily living)) as a method to measure and support daily functioning for older people living independently at home. DESIGN Systematic review. SETTING Participants' homes. PARTICIPANTS Community-dwe...

Disease control efforts directed at human immunodeficiency virus are predicated on the need to reduce personal risk behaviors; that approach may not adequately reflect the complicated interplay between personal behaviors and the social setting in which they occur. Efforts to date, including the application of population ecology, the development of the core group hypothesis, and the use of compa...

OBJECTIVE To assess the effects of preventive home visits to elderly people living in the community. DESIGN Systematic review. SETTING 15 trials retrieved from Medline, Embase, and the Cochrane controlled trial register. MAIN OUTCOME MEASURES Physical function, psychosocial function, falls, admissions to institutions, and mortality. RESULTS Considerable differences in the methodological...

Article history: Received 9 November 2012 Received in revised form 27 June 2013 Accepted 28 August 2013 Available online 27 November 2013 This study focuses on the appropriation process of two public computing infrastructures in the City of Oulu, Finland, a municipalWiFi network and large interactive displays. We analyze the adoption of these technologies in public urban places with a conceptua...