The objective of this study was to observe the apoptosis-inducing effect and mechanism of baicalin on human cervical cancer HeLa cells. The inhibitory effect of baicalin on the growth of HeLa cells was measured by MTT assay, and cell proliferation and migration was analyzed by cell scratch assay. Morphological changes of apoptotic cells were viewed by the light microscope and electron microscop...

The objective of this study was to observe the apoptosis-inducing effect and mechanism of baicalin on human cervical cancer HeLa cells. The inhibitory effect of baicalin on the growth of HeLa cells was measured by MTT assay, and cell proliferation and migration was analyzed by cell scratch assay. Morphological changes of apoptotic cells were viewed by the light microscope and electron microscop...

most contemporary clinical reasoning tests typically assess non-automatic thinking. therefore, a test is needed to measure automatic reasoning or pattern recognition, which has been largely neglected in clinical reasoning tests. the puzzle test (pt) is dedicated to assess automatic clinical reasoning in routine situations. this test has been introduced first in 2009 by monajemi et al in the oly...

background: objective structured clinical examination (osce) is one of the best methods of evaluating the achievement of domains such as educational objectives and cognitive, emotional, and psycho-motor aspects of medical students. according to available evidences, no study has been conducted  on the evaluating of osce in midwifery students. the main purpose of this study was the evaluation of ...

UNLABELLED The phosphoinositide 3-kinase (PI3K) pathway is one of the most frequently mutated pathways in cancer, and is actively being pursued as a therapeutic target. Despite the importance of the PI3K pathway in cancer, durable responses to PI3K pathway-targeted therapies are uncommon with monotherapy. Several in vitro and xenograft models have elucidated compensatory signaling and genomic c...

knowledge about the clinical significance of v-raf murine sarcoma viral oncogene homolog b1 ( braf ) mutations in colorectal cancer (crc) is growing. braf encodes a protein kinase involved with intracellular signaling and cell division. the gene product is a downstream effector of kirsten ras 1( kras ) within the ras/raf/mapk cellular signaling pathway. evidence suggests that braf mutations, li...

clinical trial committee (ctc) has been established in food and drug organization (fdo), in 2003 to assure efficacy and safety of all types of medicinal products which are meant to be registered in iran drug list and/or obtain market authorization.all clinical trial files, meeting minutes and databases in ctc secretariat in fdo were reviewed. relevant information and data extracted, analyzed an...

background: at the present time, teaching pharmacology for medical students mainly focuses on the basic principles of pharmacology. this study was conducted to assess the current situation of pharmacology teaching and the necessity of developing clinical pharmacology from the viewpoint of medical interns and externs in tabriz university of medical sciences. methods: this descriptive cross-secti...

Clinical pathway (CP) is the standard way to manage medical activities in order to improve the efficiency and minimize the cost of healthcare service. However current application of CPs can hardly adapt to the dynamic and complex clinical processes which involve the coordination of social agents in hospital. This paper focuses on developing a multi-agent modeling method to build up the system t...

Abstract Aim Rib fractures carry a mortality rate of 10% which is doubled in the elderly population. They are common following blunt thoracic trauma and marker injury severity. Timely delivery regional analgesia crucial to prevent secondary respiratory complications. We compare time taken from admission administration block patients with >2 rib before after implementation fracture pathwa...