Since the early descriptions of thought disorder in psychiatric patients were recorded by clini-cians such as Bleuler and Kraepelin, numerous studies have attempted to examine this phenomenon through the use of various techniques. Harvey (1983) suggests that three main methods have been used to assess thought disorder. Clinical investigations of deviant communication patterns and natural langua...

You You ' ' ve heard a lot about NI trials already, so I ve heard a lot about NI trials already, so I ' ' ll try not to ll try not to repeat. The critical issues are, by now known to you: repeat. The critical issues are, by now known to you: 1. In most cases NI trials pose inferential problems, but 1. In most cases NI trials pose inferential problems, but you use them when you have no choice, i...

To the Editor: In response to the Letter by Eross et al. (1): we appreciate their comments on our work with glycated hemoglobin (gHb) from blood samples dried on filter paper (2, 3) but we believe that some important points in our paper were missed. We, too, have had extensive experience with the thiobarbituric acid (TBA) method (4-7) and have used it with blood samples dried on glucose oxidase...

tion was associated with an observable survival benefit and delay in progression to AIDS among HIV-1–infected IDUs. 3 While HTLV-I has been definitively proven to cause adult T-cell leukemia/lym-phoma and a progressive neurodegenerative illness known as tropical spastic parapare-sis/HTLV-I–associated myelopathy (TSP/ HAM), a causal role for HTLV-II with either leukemia or TSP/HAM is much less w...

T he diabetes pandemic is currently among the most challenging noncommunicable disease threats to public health. It is estimated that 382 million people worldwide have diabetes mellitus, and the majority will likely die of cardio-vascular disease. Diabetes mellitus is an independent risk factor for atherosclerotic cardiovascular disease and heart failure, with a 5-fold increased risk of heart f...

This is a very impressive and comprehensive text on the breast and breast cancer, which is now in its fifth edition. This book has already become a classic reference text and should grace the bookshelf of every professional looking after women and men with breast cancer. Any book in its fifth edition will of necessity carry its history with it. The Introduction, and chapters on benign breast di...

and progressive dementia, occurring after age 40, associated , as in kuru, with plaques in the brain of affected * Department of Genetics and Howard Hughes Medical Institute individuals (Gerstmann et al., 1936). Multiple affected family members were observed, in a pattern indicating Yale University School of Medicine New Haven, Connecticut 06510 autosomal-dominant inheritance. Similar genetic t...

projects in the various workpackages and clinical cohorts have been launched as planned and the emphasis now is on strengthening the interactions and collaborations between basic scientists and clinicians. Accordingly, a major effort of the NCCR has been to support initiatives that aim at a culture of sharing data and competences in particular by establishing common platforms that could be appl...

G reat strides have been made in the past 10 years in North America, Asia, and Europe in neurologic-rehabilitation-related research. Neurorehabilitation and Neural Repair (NNR) aims to foster this far-reaching scientific activity. As the new editor in chief, with outstanding associate editors and editorial board members, I will continue the course set by Dr Mickey Selzer to capture the most imp...

Down syndrome (DS) is the most common genetically driven intellectual disability. Neuro pathological evidence of an associa‐ tion between Alzheimer disease (AD) and DS was published 11 years before trisomy 21 was described as the cause of DS.1 AD‐type pathology is almost universal in patients with DS in their 40s, although the develop ment of clinically detectable cognitive decline typically la...