BACKGROUND The so-called community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains are more frequently susceptible to non-ss-lactam antibiotics (including clindamycin) than health care-associated MRSA strains. We assessed whether predictive clinical characteristics of presumptive MRSA infections can be identified to guide choice of empiric antibiotic therapy. METHODS A c...

The study was conducted to determine the post antibiotic effect (PAE) of clindamycin and/or chlorhexidine against clinical isolates of oral streptococci. The PAE period was determined by spectrophotometric technique. A prolonged period of PAE (4h) was demonstrated when the isolate of Streptococcus mutans was exposed for an hour at a concentration of 4XMIC of clindamycin. While exposure to clind...

background: clindamycin inducible resistant staphylococcus aureus (s.aureus) isolates can cause failure in treatment with this antibiotic. biofilm production via polysaccharide intercellular adhesion (pia) contributes in the colonization of s. aureus, resulting in the initiation of different diseases. the aim of this study was to detect icaadbc genes among isolates of s.aureus with inducible re...

BACKGROUND AND OBJECTIVES Accurate designation of antimicrobial susceptibility pattern of the infecting microorganisms is an important crucial factor in making appropriate therapeutic decisions. Macrolide, lincosamide and streptogramin B antibiotics are in a family, reserved as an alternative approach in treatment of resistant Gram positive cocci. Amongst them, clindamycin has been considered a...

OBJECTIVE To test the efficacy of treatment with clindamycin of a partner on the recurrence rate of bacterial vaginosis in women within 3 months from diagnosis. SUBJECTS Eligible for the study were sexually active women with one current sexual partner, who were aged 18-45 years, with a clinical diagnosis of bacterial vaginosis and whose partner agreed to be treated. METHODS A double blind, ...

Moxifloxacin penetrates well into oromaxillary tissue and covers the causative pathogens that show an increasing resistance to standard antibiotics. Clinical reports suggest that moxifloxacin may be effective for the treatment of odontogenic infections that can lead to serious complications. The objective of this prospective, randomized, double-blind, multicenter study was to compare the effica...

BACKGROUND Widespread antibiotic use has been associated with increases in both bacterial resistance and nosocomial infection. OBJECTIVE To characterize the impact of hospital-wide clindamycin restriction on the incidence of Clostridium difficile-associated diarrhea and on antimicrobial prescribing practices. DESIGN Prospective, observational cohort study. SETTING University-affiliated Ve...

In 2012, blood, skin and soft tissue infections caused by clindamycin resistant Streptococcus pyogenes (group A streptococcus; GAS) appeared to be increasing in the Helsinki metropolitan area. We compared monthly percentages of clindamycin resistant isolates in the area between 2012 and 2013, with those in 2010 and 2011. Resistance frequency in terms of patient age was also studied. We reviewed...

BACKGROUND Gentamicin reduces acetylcholine release and clindamycin causes end-plate ion channel blockade. Because of these reasons, two drugs show muscular relaxant effect and potentiate the action of nondepolarizing neuromuscular agents. This study was intended to evaluate the effect of gentamicin and clindamycin on rocuronium-induced neuromuscular blockade and the interaction between these d...

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infection occurs commonly in children. Clindamycin resistance may be inducible or constitutive, and the rates of inducible resistance in CA-MRSA that could produce clindamycin treatment failures vary worldwide. The double-disk test was performed in 197 erythromycin-resistant and clindamycin-susceptible CA-MRSA strains from...