The presence of a cleft lip, cleft palate or both, has a huge impact on the life of an individual and their family. Modern management has much to offer these people, revolutionizing appearance and functional defects to a point where they may be difficult to detect. Surgery aims to correct the anatomically obvious cleft lip, augment normal dento-alveolar development and lead to effective palatal...

Congenital cleft-Lip and cleft palate has been the subject of many genetic studies, but until recently there has been no consensus as to their modes of inheritance. In fact, claims have been made for just about every genetic mechanism one can think of. Recently, however, evidence has been accumulating that favors a multifactorial basis for these malformations. Cleft lip and palate (CLP) are bir...

OBJECTIVE Mutations in exon 1 of ARHGAP29, a RhoA specific GTPase have been identified in North American and Filipino subjects with nonsyndromic cleft palate and cleft lip with or without cleft palate. Since the genetic status of ARHGAP29 in Indian subjects with nonsyndromic oral clefts is not known, we designed the present study to investigate the occurrence of the above mutations in them. M...

In a child with cleft lip and/or palate, nutrition is the first priority as for any other child. These children have specific physical limitations. To fulfill their nutritional requirement, these children need modifications in order to thrive and grow. Failure to adjust to these needs could place the children into a potential life-threatening situation. One of the immediate problems to be addre...

Clefting of the secondary palate is one of the most common human birth defects and results from failure of the palatal shelves to fuse during embryonic development. Palatogenesis is traditionally considered to be a highly conserved developmental process among mammalian species. However, cleft palate phenotypes in humans are considerably more variable than those seen in mice, the most common ani...

INTRODUCTION The classic submucous cleft palate triad was described by Calnan in 1954. The findings include a bifid uvula, a bony notch in the posterior hard palate, and a furrow along the midline of the soft palate. The furrow represents an area of diastasis of the velopharyngeal muscle sling and is often referred to as the zona pellucida. In 1975, Kaplan first reported on the ‘‘occult’’ submu...

OBJECTIVE To review the cephalometric studies investigating the craniofacial morphology of the parents of children with cleft lip and/ or palate (CL(P)). METHODS A review of the literature has been conducted using MedLine sources dated 1970-2005. The Cleft Palate-Craniofacial Journal has been searched manually. The reference lists of all previous publications were consulted to identify any pu...

Cleft lip and palate is one of the most common birth defects occurring 1 of every 700 live births. Historically, cleft lip and palate care typically involves the use of presurgical infant orthopedics appliances (PIOA) fabricated by a pediatric dentist as an adjunct to the overall management of the defect approximate the cleft segments prior to surgical repair. However, the necessity of presurgi...

A population-based case-control study was carried out in Norway between 1996 and 2001. The aim was to evaluate the association between maternal intake of vitamin A from diet and supplements and risk of having a baby with an orofacial cleft. Data on maternal dietary intake were available from 535 cases (188 with cleft palate only and 347 with cleft lip with or without cleft palate) and 693 contr...

Background: Cleft deformities (lip and palate) have been reported to be the most common congenital craniofacial anomaly in several settings. In Uganda, though two previous studies were conducted to determine the incidence of cleft lip and palate, the estimates obtained from those studies may not be precise given the study settings. This study was undertaken to establish the incidence of cleft d...