Software protection is an area of active research in which a variety of techniques have been developed to address the issue. Examples of such techniques include code obfuscation, software watermarking, and tamper detection. In this paper we propose a tamper resistance technique which provides both on and offline tamper detection. In our offline approach, the software dynamically detects tamperi...

In situ, cells of the musculoskeletal system reside within complex and often interconnected 3-D environments. Key to better understanding how 3-D tissue and cellular environments regulate musculoskeletal physiology, homeostasis, and health is the use of robust methodologies for directly visualizing cell-cell and cell-matrix architecture in situ. However, the use of standard optical imaging tech...

The debts’ clearing problem is about clearing all the debts in a group of n entities (persons, companies etc.) using a minimal number of money transaction operations. The problem is known to be NP-hard in the strong sense. As for many intractable problems, techniques from the field of artificial intelligence are useful in finding solutions close to optimum for large inputs. An evolutionary algo...

A possible relationship may exist between the concentration of heparin-activated plasma clearing factor and alterations in lipid metabolism associated with advancing age, atherosclerosis, and other diseases. To test this hypothesis, 121 men were evaluated in the development and application of a standardized in vitro method for the determination of clearing factor response to minimal heparin sti...

We study algorithms for combinatorial market design problems, where a set of heterogeneous and indivisible objects are priced and sold to potential buyers subject to equilibrium constraints. Extending the CWE notion introduced by Feldman et al. [STOC 2013], we introduce the concept of a Market-Clearing Combinatorial Walrasian Equilibium (MC-CWE) as a natural relaxation of the classical Walrasia...

Parkinson's disease is a devastating neurodegenerative disorder characterized by loss of neuromelanin-containing dopaminergic neurons. Novel 3D culture systems like human midbrain-like organoids (hMOs) enable new research avenues for patient-specific therapies, but cannot reach their full potential unless rapid optical imaging entire enabled. Currently, hMOs have to undergo tissue clearing proc...

Multiphoton microscopy of intrinsic fluorescence and second harmonic generation (SHG) of whole mouse organs is made possible by optically clearing the organ before imaging.(1,2) However, for organs that contain fluorescent proteins such as GFP and YFP, optical clearing protocols that use methanol dehydration and clear using benzyl alcohol:benzyl benzoate (BABB) while unprotected from light(3) d...