Received: Revised: Accepted: Published online: June 07, 2017 August 10, 2017 August 12, 2017 September 23, 2017 The gastrointestinal tract of poultry is inhabited by a diverse community of bacteria, fungi, protozoa and viruses. The aim of the study was to determine the influence of early antimicrobial treatment on the fungal microflora of the gastrointestinal tract of turkeys and analyze candid...

A simple and sensitive high performance liquid chromatographic method with electrochemical detection is described for the quantitative determination of the amoxycillin and clavulanic acid in pharmaceutical dosage forms. Separation of sample components occurs on a reversed phase C18 column with a mobile phase consisting of methanol-water-phosphate buffer. For the amperometric detection, the pote...

OBJECTIVE To compare clinical response to initial empiric treatment with oxacillin plus ceftriaxone and amoxicillin plus clavulanic acid in hospitalized children diagnosed with very severe community-acquired pneumonia (CAP). METHODS A prospective randomized clinical study was conducted among children 2 months to 5 years old with a diagnosis of very severe CAP in the pediatric ward of São Paul...

As part of a search for transcriptional regulatory genes, sequence analysis of several previously unsequenced gaps in the cephamycin biosynthetic cluster has revealed the presence in Streptomyces clavuligerus of seven genes not previously described. These include genes encoding an apparent penicillin binding protein and a transport or efflux protein, as well as the CmcI and CmcJ proteins, which...

Chlamydia trachomatis, the most common bacterial sexually transmitted disease agent worldwide, enters a viable, non-dividing and non-infectious state (historically termed persistence and more recently referred to as the chlamydial stress response) when exposed to penicillin G in culture. Notably, penicillin G-exposed chlamydiae can reenter the normal developmental cycle upon drug removal and ar...

Reports of ESBL (extended spectrum β-lactamase) producing E. coli strain in UTI (urinary tract infections) patients is increasing. This study determines the presence of ESBL in E. coli isolates from UTI patients. A total of 414 cultured urine samples were collected from hospital. E. coli was isolated from these cultures using conventional microbiological tools. These antibiotics of third genera...

OBJECTIVES Although most susceptibility studies for linezolid have investigated aerobic bacteria, only a few have investigated anaerobe isolates. The aim of the present study was to determine the antibacterial activity of linezolid against a larger sample of clinical isolates of Fusobacterium spp. and to report on the detailed susceptibility, stratified by species. METHODS The in vitro suscep...

LK-157 is a novel tricyclic carbapenem with potent activity against class A and class C -lactamases. When tested against the purified TEM-1 and SHV-1 enzymes, LK-157 exhibited 50% inhibitory concentrations (IC50s) in the ranges of the clavulanic acid and tazobactam IC50s (55 nM and 151 nM, respectively). Moreover, LK-157 significantly inhibited AmpC -lactamase (IC50, 62 nM), as LK-157 was >2,00...