Classification & definition of premature ejaculation Premature ejaculation (PE) can be broadly classified as ‘lifelong’ (primary), characterized by onset from the first sexual encounter and persisting throughout life, or ‘acquired’ (secondary), which tends to have either a gradual or sudden onset following previously normal ejaculation [1,2]. Several definitions of PE exist, including the widel...

James H. Barada Ejaculation, representing the physiologic means of semen and sperm delivery for reproduction has, until recently, received relatively little attention in the area of male sexual health. Yet, ejaculatory dysfunction, or male orgasmic disorder (MOD), is one of the most common male sexual disorders. The spectrum of MOD extends from premature ejaculation through various manifestatio...

BACKGROUND AND AIMS Selective serotonin reuptake inhibitors (SSRIs) are one of the most prescribed classes of psychotropics. Even though the SSRI class consists of 6 molecules (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine and sertraline), only fluoxetine was intensively studied for endocrine disruptive effects, while the other SSRIs received less attention. This study was desig...

Indian Dhat syndrome which is symptom complex most commonly seen in younger group of patients in between 16 to 23 years of age. These patients present with whitish discharge with urine (patients believe it to be semen). This is associated most commonly with impotency, marked anxiety, general weakness, premature ejaculations and hypochondriasis. All the patients were either from low or average s...

BACKGROUND Bleeding is the most common and worrisome adverse effect of warfarin therapy. One of the factors that might increase bleeding risk is initiation of interacting drugs that potentiate warfarin. We sought to evaluate whether initiation of an antidepressant increases the risk of hospitalization for gastrointestinal bleeding in warfarin users. METHODOLOGY/PRINCIPAL FINDINGS Medicaid cla...

PURPOSE Previous studies have revealed that tamsulosin is effective in improving lower urinary tract symptoms (LUTS) and erectile functioning but has some inhibitory effects on ejaculation, including decreased ejaculatory volume. However, these inhibitory effects on ejaculation can be beneficial to patients with premature ejaculation (PE). Therefore, this study was conducted to understand the e...

Selective serotonin reuptake inhibitors and venlafaxine are currently considered as first-line agents for patients with panic disorder (PD). However, a systematic comparison of newer antidepressants for the treatment of PD is lacking thus far. Eligible studies focusing on PD patients treated with newer antidepressants were entered in the Cochrane Collaboration Review Manager. Our primary outcom...

      Anti-inflammatory activity has been reported for a few of antidepressant drugs and in contrary sertraline has potentiated inflammation. In this study, anti-inflammatory effect of a collection of antidepressant drugs belonging to different classes was evaluated to help a rational selection of these drugs in disease conditions such as association of depression or anxiety with inflammatory d...