BACKGROUND Immunosenescence is a process that affects all cell compartments of the immune system and the contribution of the immune system to healthy aging and longevity is still an open question. Lymphocyte subpopulations present different patterns of circadian variation and in the elderly alteration of circadian rhythmicity has been evidenced. The aim of our study was to analyze the dynamics ...

Ito M. Circadian variation of QT interval dispersion: correlation with heart rate variability. J Electrocardiol 1997; 30: 205–10. [9] Cinca J, Moya A, Figueras J, Roma F, Rius J. Circadian variations in the electrical properties of the human heart assessed by sequential bedside electrophysiologic testing. Am Heart J 1986; 112: 315–21. [10] Huikuri HV, Yli-Mayry S, Linnaluoto MK, Ikaheimo MJ. Di...

BACKGROUND In a new preparation of prenatal multivitamins, PregVit, two tablets a day (a.m. and p.m.) are given. Folic acid is separated from iron and zinc and is given in the p.m. tablet to overcome problems due to folic acid interactions with iron or zinc, and frequent presence of nausea and vomiting of pregnancy in the morning. The circadian variation of folate in humans has not been investi...

BACKGROUND The circadian variation in urinary leukotriene E(4) (LTE(4)) excretion with a morning acrophase has recently been reported in nocturnal asthma (NA); however, the effects of inhaled corticosteroids (ICS) on this circadian rhythmicity of leukotriene (LT) in patients with NA are controversial. METHODS We first measured peak expiratory flow (PEF), urinary LTE(4), 11-dehydro-thromboxane...

Circadian clock genes use transcriptional-translational feedback loops to control circadian rhythms. Recent studies have demonstrated that expression of some circadian clock genes displays daily oscillation in peripheral tissues including peripheral blood and bone marrow. Circadian rhythms regulate various functions of human body, and the disruption of circadian rhythm has been associated with ...

The study of the day and night cycle and its effects on the human body has been a field of interest for many decades. In more recent years, the effects of these diurnal variations have been looked into with respect to human skin. To encourage future medical interest in this subject as well as to discuss the futuristic concept of transdermal drug delivery incorpo­ rating the effects of circadian...

Although homeostasis is a commonly accepted concept, there incontrovertible evidence that biological processes and functions are variable variability occurs in cycles. In order to explain understand dysregulation, which has not been embraced by homeostatic principles, the allostatic model emerged as first serious challenge homeostasis, going beyond its roots. Circadian rhythm predominant variat...