Chrysin (CH), a natural plant flavonoid, has shown a variety of beneficial effects. Our present study was conducted to evaluate the therapeutic potential of CH three days after spinal cord injury (SCI) in rats and to probe the underlying neuroprotective mechanisms. SCI was induced using the modified weight-drop method in Wistar rats. Then, they were treated with saline or CH by doses of 30 and ...

ISSUES Polyphenolic compounds, especially flavonoids, are known as the most common chemical class of phytochemicals, which possess a multiple range of health-promoting effects. Flavonoids are ubiquitous in nature. They are also present in food, providing an essential link between diet and prevention of several diseases. APPROACH Chrysin (CH), a natural flavonoid, was commonly found in propoli...

We assessed the effects of 24 flavonoid derivatives, reported as anti-inflammatory, on lysosomal enzyme secretion and arachidonic acid release in rat neutrophils. Amentoflavone, quercetagetin-7-O-glucoside, apigenin, fisetin, kaempferol, luteolin and quercetin were the most potent inhibitors of beta-glucuronidase and lysozyme release. The first compound was also able to inhibit basal release. T...

Three flavonoidal aglycones viz; F1 (Chrysin), F2 (Kampferol) and novel F3( 3,7dimethylether quercetin), were isolated from acetone wash of fresh leaves of Datura stramomium L. Isolated compounds were identified on the basis of their physico-chemical properties, Co-TLC, H-NMR, C-NMR and CIMS specrtum. Significant cytotoxic activity against three tumor cell lines (liver, cervix & breast), was re...