BACKGROUND Polymicrobial communities colonize all wounds, and biofilms are hypothesized to be a key link to the chronic state and stalled healing. Molecular methods offer greater insight when studying microbial ecology in chronic wounds, as only a small fraction of wound bacteria are cultured by currently available methods and studies have shown little agreement between culture and molecular ba...

Wound healing can be problematic in several clinical settings because of massive tissue injury (burns), wound healing deficiencies (chronic wounds), or congenital conditions and diseases. Engineered skin substitutes have been developed to address the medical need for wound coverage and tissue repair. Currently, no engineered skin substitute can replace all of the functions of intact human skin....

Skin wounds are categorized as 'acute' or 'chronic' based on the healing process. Wound care is of utmost importance break in skin barrier exposes internal milieu to various commensal and pathogenic microbes. The usage nanomaterials a recent approach facilitate wound by processes that operate singly tandem. Metal show antibacterial, antifungal, anti-inflammatory activities; organic-inorganic, o...

BACKGROUND AIMS Recalcitrant diabetic wounds are not responsive to the most common treatments. Bone marrow-derived stem cell transplantation is used for the healing of chronic lower extremity wounds. METHODS We report on the treatment of eight patients with aggressive, refractory diabetic wounds. The marrow-derived cells were injected/applied topically into the wound along with platelets, fib...

Since its inception, osteopathic medicine has been concerned with the lymphatic system. Research has demonstrated the effectiveness of lymphatic osteopathic manipulative treatment (OMT) techniques in affecting fluid management and immune function. Many of the functions provided by the lymphatic system and augmented by OMT are necessary for proper wound healing. The authors highlight the unique ...

Chronic wounds occur when one wound healing process or a sequence of events are affected resulting in slow the thereby placing patient deep pain. Various diseases and conditions can delay healing. Wound be classified into four main stages: hemostasis, inflammation, remodeling, scar tissue formation with each phase overlapping another. The skin is largest organ body. It protects entire external ...

Problems with exudate production occur if the wound becomes ‘stuck’ in the inflammatory stage and the production of exudate is overstimulated. Exudate found in chronic wounds (those that fail to heal after six weeks) has a different makeup to that in acute wounds and is often produced in higher quantities. Chronic wound exudate does not have the active growth factors found in acute wound exudat...

The aim of this study was to develop a short questionnaire measuring health-related quality of life (HRQoL) in chronic wounds. Three validated instruments assessing HRQoL in chronic wounds-the Freiburg Life Quality Assessment for wounds, the Cardiff Wound Impact Schedule, and the Würzburg Wound Score-were completed by 154 German leg ulcer patients in a longitudinal study. For implementation in ...

This article builds and expands upon the concept of wound bed preparation introduced by Sibbald et al in 2000 as a holistic approach to wound diagnosis and treatment of the cause and patient-centered concerns such as pain management, optimizing the components of local wound care: Debridement, Infection and persistent Inflammation, along with Moisture balance before Edge effect for healable but ...