wounds and wound healing have always been one of the most important subjects that experimental researches were dedicated to. simvastatin has been used for long as a common lipid lowering agent which was reported to have some pleiotropic effects such as antioxidation, anti-inflammation and immunomodulation. in this study we aimed to determine the effect of simvastatin on wound healing process in...

burns are a worldwide problem. the incidence of severe burns has been higher than the combined incidence of tuberculosis and hiv infections. throughout history there have been many different treatments prescribed for burns. the canon is the masterpiece of avicenna’s medical books. the canon includes a description of 785 simple drugs. avicenna believed in burn treatment, which follows two goals....

BACKGROUND Wound healing trajectories (percent healing vs time) provide a dynamic picture of the decrease in wound burden over the entire continuum of the healing process. Trajectories can be robustly compared using survival statistics methodology. Improvement in healing can be determined by shifting the curve from "impaired" healing toward "ideal" healing. Although this concept of shifting the...

This study investigated whether peripheral nerve damage in patients with leprosy impairs local cellular immune responses, thereby reducing wound healing and leading to chronic skin ulceration. Anesthetic and contralateral sensitive skin sites in 42 patients with leprosy were compared for delayed-type hypersensitivity responses to purified protein derivative (PPD) of tuberculin. Leukocyte recrui...

Molecular Regulation of Wound Healing Wound healing in the skin is a complex biological process involving inflammation, chemotaxis of cells, mitosis of epidermal, dermal and vascular cells, neovascularisation, synthesis of extracellular matrix proteins and remodelling of scar tissue. Growth factors, cytokines, proteases and hormones have been shown to regulate most aspects of these processes in...

Wound healing is a complex and well-orchestrated process to keep our skin intact. This delicate repair often gets disrupted in patients with underlying causes. However, the effective wound therapy lacking due limited knowledge of related molecular pathogenesis. In this study, we performed paired small RNA (miRNA) long (circular mRNA) sequencing human tissue samples, including matched acute woun...

Accurate and clinically practical methods for measuring the progress of acute wound healing is necessary before interventions designed to optimize and even accelerate acute wound healing can be applied. Complete wound closure rates and operative wound closure severity are irrelevant to most acute wounds since most are closed at the time of primary tissue repair and remain closed throughout heal...

Chronic ulcers are a major problem in health care worldwide [1–5]. Wound care is a much neglected field in Sri Lanka. Care of a wound, and advising and supervising the medical team to carry out the necessary measures in wound care, is a basic duty of a clinician. Wounds are an ideal opportunity to demonstrate the ‘art and science of healing’. Patients with chronic wounds are often shunned by th...

Background: Equine wounds, particularly those involving the distal portion of the limbs, often undergo prolonged complex healing and may enter a non-healing state with obvious financial and welfare implications. Poor blood supply and lower levels of oxygen to the lower limbs lead to imbalance of growth factors related to wound healing. Decellular amniotic membrane has been widely used in soft t...

OBJECTIVE To systematically examine the clinical effectiveness and safety of negative pressure wound therapy (NPWT) compared with conventional wound therapy. DATA SOURCES MEDLINE, EMBASE, CINAHL, and the Cochrane Library were searched. Manufacturers were contacted, and trial registries were screened. STUDY SELECTION Randomized controlled trials (RCTs) and non-RCTs comparing NPWT and convent...