Blood, Vol. 50, No. 1 (July), 1977 115 The specificity of an antiserum (titer 1:500) raised in a monkey against K-562 undifferentiated cells with the Philadelphia chromosome (Ph’) was determined. Antibody-dependent, complement-mediated cytotoxicity was demonstrated for both bone marrow cells and peripheral leukocytes from patients with myelogenous and lymphatic leukemias, but not for mature nor...

Objective: Proteasomal system is the primary protein degradation mechanism and important for cellular homeostasis. On other hand, increased proteasome activity protects cancer cells from cell death. The objective of this preliminary study was to determine response proteasomal oxidative stress in human lines including K562 chronic myelogenous leukemia, U251 glioblastoma, DU145 prostate cancer, H...

Background Myelodysplastic syndromes are clonal myeloid disorders marked by ineffective hematopoiesis, cytopenia and qualitative disorders of blood cells that have a variable predilection to undergo clonal evolution to acute myelogenous leukemia. Chronic infection with hepatitis C virus (HCV) induces a chronic stimulation of B lymphocytes and, in some cases, this stimulation can lead to chronic...

A novel colorimetric assay was established based on folic acid-conjugated porous Pd@Au nanoparticles possessing peroxidase-like activity as labels for the rapid detection of human chronic myelogenous leukemia cell lines (K-562).

associations of some hematological and lymphatic diseases with sex and abo and rh blood groups were studied in 2579 patients, compared with a control group of 126332 individuals, by the use of clinical as well as laboratory findings, in tehran. highly significant increase of male/female ratio is shown in acute myelogenous leukemia, acute lymphocytic leukemia, chronic lymphocytic leukemia, aplas...

Chronic myelogenous leukemia (CML) is a type of leukemia originating from hematopoietic stem cells characterized by unregulated proliferation of myeloid cells. Leukemic cells carry the chromosome, a translocation between one chromosome 9 and one chromosome 22. This chromosome has the fusion gene which consists of fragments of the breakpoint cluster region (BCR) and abelson murine leukemia (ABL)...