Generalized pain especially in a periodic manner is a confusing entity challenging pediatricians to cover an extensive range of disorders including simply follow-up cases like “Growth Pain” to life threatening, hideously progressing hematologic malignancies [1]. This paper, however, aims to point out another entity in this range that is often to be missed and misplaced under other categories. E...

In an attempt to explain how and why some individuals with musculoskeletal pain develop a chronic pain syndrome, Lethem et al. (Lethem J, Slade PD, Troup JDG, Bentley G. Outline of a fear-avoidance model of exaggerated pain perceptions. Behav Res Ther 1983;21:401±408) introduced a so-called `fear-avoidance' model. The central concept of their model is fear of pain. `Confrontation' and `avoidanc...

BACKGROUND Traditionally, non-communicable diseases including musculoskeletal disorders have not been a priority in low-and-middle income countries. The main aim of this paper is to assess age and gender specific burden by estimating the current prevalence of musculoskeletal disorders and associated risk factors in the elderly Ghanaian population. METHODS Between May 2007 and June 2008, the W...

Background: Stem cells has previously been used with promising results as a therapeutic modality for neurodegenerative diseases and pain but recently introduced treatment chronic pain. Objective: This study aims to review the available literature on role of stem cell therapy Methods: A clinical reports using PRISMA (Preferred Reporting Items Systematic Review Meta-Analysis) method published in ...

Sleep disturbance is an important clinical complaint for individuals with nonmalignant pain conditions. This review is a broad introduction to the literature on sleep disturbance and chronic pain conditions. The article critically reviews studies of sleep disturbance in musculoskeletal pain, arthritis, headache, and fibromyalgia. Current neurobiological hypotheses regarding the pathogenesis of ...

Treatments for chronic musculoskeletal pain, such as lower back pain, fibromyalgia, and myofascial pain syndrome, remain inadequate because of our poor understanding of the mechanisms that underlie these conditions. Although T-type Ca2+ channels (T-channels) have been implicated in peripheral and central pain sensory pathways, their role in chronic musculoskeletal pain is still unclear. Here, w...

BACKGROUND Chronic musculoskeletal pain is highly prevalent, disabling, and costly, and has many negative effects on quality of life. The aim of this study was to investigate factors associated with higher reported pain levels in patients with chronic musculoskeletal pain among demographic, clinical, and psychological factors, and to evaluate whether insomnia is independently associated with pa...

INTRODUCTION Chronic musculoskeletal pain is a common condition that often responds poorly to treatment. Self-management courses have been advocated as a non-drug pain management technique, although evidence for their effectiveness is equivocal. We designed and piloted a self-management course based on evidence for effectiveness for specific course components and characteristics. METHODS/ANAL...