Several syndromes manifest as recurrent daily fevers, skin lesions, and multisystem inflammation. We describe 4 patients with early-onset recurrent fevers, annular violaceous plaques, persistent violaceous eyelid swelling, low weight and height, lipodystrophy, hepatomegaly, and a range of visceral inflammatory manifestations. Laboratory abnormalities included chronic anemia, elevated acute-phas...

Xanthogranulomatous pyelonephritis is an uncommon chronic inflammatory renal disorder caused by chronic infection with gram-negative bacteria leading to destruction of the renal parenchyma and replacement with foamy lipid-laden macrophages. Renal malakoplakia is another rare form of chronic inflammatory granulomatous disease in the kidney associated with infection usually occurring in adults wi...

Among the main groups of chronic somatic diseases, it is rheumatological diseases that make biggest contribution to aggravation health. In structure causes for primary disability, pathology ranks second position after cardiovascular diseases. Gout a chronic, progressive disease associated with purine metabolism disorder, characterized by an increase in level uric acid blood (hyperuricemia) and ...

Pyoderma vegetans (PV) is a rare inflammatory disorder characterized by vegetating pustules and plaques affecting the skin and mucosal membranes. It is believed that this entity is mostly associated with inflammatory bowel disease (IBD), chronic malnutrition, human immunodeficiency virus (HIV), malignancies, and other immunocompromised states. Pyoderma vegetans occurs more commonly in young and...

Surgical injury evokes an injury response involving immunologic mechanisms. Alterations in the immune response after surgery are recognized as physiological reactions of the organism to restore its homeostasis. The immune responses are characterized by the release of cytokines, inflammatory mediators and acute-phase proteins. The activation of immune cells is followed by the release of various ...

coronary  atherosclerotic  disease  is  one  of  the  most  endangering  health  disorder worldwide. this study was designed to investigate the correlation between hla-drβ1 alleles and circulating th1/th2 type cytokines in coronary atherosclerosis. by elisa, th1/th2 type cytokines were determined in serum samples of 31 subjects with unstable angina, 27 subjects with chronic stable angina and 24...

asthma is a chronic inflammatory and remodeling disorder of the airways, in which many cells, cellular elements, and cytokines play important roles. the role of tumor necrosis factor- α (tnf-α) in asthma is unclear in pakistani population. the aim of this study was to assess the relationship between tnf-α -308 polymorphism and asthma.polymorphism of tnf-α (g-308-a locus; rs 1800629) in 329 asth...

rheumatoid arthritis is a chronic systemic inflammatory disease that affects approximately 0.5-1% of the world population. the current approach to this disease is to start an intensive treatment without delay once the disease has developed. various studies in the literature have shown that combination of disease modifying antirheumatic drugs such as sulfasalazine and chloroquine offers a more a...

Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent, and debilitating skin disease of the hair follicle unit that typically develops after puberty. The disorder characterized by comedones, painful inflammatory nodules, abscesses, dermal tunnels, scarring, with predilection for intertriginous areas body (axillae, inguinal, anogenital regions). Recruitment neutrophils to HS lesion...

Introduction: Chronic Non-Bacterial Osteomyelitis (CNO) is a rare inflammatory disorder not related to any infectious disease characterized by focal aseptic inflammation with self-limiting, relapsing course of female predominance and usually observed in paediatric age groups diagnosed clinical, radiological histopathological findings after ruling out all other differentials.Case Report: A case ...