BACKGROUND & OBJECTIVE The recent discovery of a novel parenterally transmitted, unenveloped, single-stranded DNA virus called TT virus (TTV) in chronic hepatitis patients with unclear pathogenesis throughout the world led us to investigate, its presence in chronic hepatitis patients attending a hospital in New Delhi, India, and to evaluate its role in liver disease. METHODS TT virus DNA was ...

conclusions the study results indicated that the neonatal hbv immunization induced a long-term protection against hbv and was very efficacious in reducing chronic hbv infection rate in vaccinated young adults in iran. results anti-hbs seropositivity rate was detected in 224 of 510 [95% ci: 39-47] young adults. breakthrough infection (positive sera for anti-hbc without chronic infection) was obs...

OBJECTIVES A number of studies have shown that chronic hepatitis B virus infection is implicated in susceptibility to pancreatic cancer. However, the results are still controversial. This meta-analysis aimed to quantitatively assess the relationship between chronic hepatitis B virus infection and incidence of pancreatic cancer of cohort and case-control studies. METHODS A literature search wa...

BACKGROUND Hepatitis B virus infection is a very common cause of chronic liver disease worldwide. It is estimated that 3% of Iranians are chronically infected with hepatitis B virus. Current population-based studies on both rural and urban prevalence of hepatitis B virus infection in Iran are sparse with results that do not always agree. We performed this study to find the prevalence of hepatit...

context the pnpla3 i148m variant has been recognized as a genetic determinant of liver fat content and a genetic risk factor of liver damage progression associated with steatohepatitis. the i148m variant is associated with many chronic liver diseases. however, its potential association with inflammatory and autoimmune liver diseases has not been established. evidence acquisition we systemically...

background: more than 350 million people are chronic carriers of hepatitis b virus (hbv) and because of the high hbv-related morbidity and mortality, the global disease burden of hbv is substantial. in patients with hbeag–negative chronic hepatitis b (chb) with serum alanine aminotransferase (alt) levels, 1-2 × upper limit of normal (uln) and hbv dna load of 10000 to 100000 copies/ml, liver bio...

This study assessed the seroepidemiology of Toxoplasma gondii, Hepatitis B Virus and their co-infection infection in women of child-bearing age in communities in Osun State, Nigeria. The study also determines the factors that facilitate the organisms among the studied groups and possible interaction between the prevalence of infection and the risk factors. These were done with a view to providi...

Although newer and more effective treatments are now available for hepatitis C virus (HCV) infection, non-HCV viral hepatitis remains an important cause of liver disease, especially among HIV-infected individuals. Hepatitis B virus (HBV) is the leading cause of cirrhosis worldwide, and approximately one-quarter of patients with cirrhosis develop decompensated liver disease within 5 years. Initi...

conclusions the mir-155 appeared to be suppressed during hbv infection. the significantly higher mir-155 levels in alt-elevated patients infected with hbv suggest that mir-155 levels in pbmcs correlate with the immune state of patients with chronic hbv infection. results in the hbv-infected patients, the mir-155 levels were significantly lower than in the healthy controls (p = 0.001). chronic h...

Chronic hepatitis B is still a major public health issue despite the successful prophylactic vaccination attempts. Chronicity of hepatitis B virus (HBV) is mainly due to its ability to debilitate host's immune system. Therefore, major measures have been taken to stop this process and help patients with chronic hepatitis B infection recover from their illness. While satisfactory results have bee...