نتایج جستجو برای: chronic cerebral hypoperfusion

تعداد نتایج: 671218  

2015
Kensuke Toyama Nobutaka Koibuchi Yu Hasegawa Ken Uekawa Osamu Yasuda Daisuke Sueta Takashi Nakagawa Mingjie Ma Hiroaki Kusaka Bowen Lin Hisao Ogawa Hidenori Ichijo Shokei Kim-Mitsuyama

Although high-fat diet intake is known to cause obesity and diabetes, the effect of high-fat diet itself on cognitive function remains to be clarified. We have previously shown that apoptosis signal-regulating kinase 1 (ASK1) is responsible for cognitive impairment caused by chronic cerebral hypoperfusion. The present work, by using ASK1 deficient mice, was undertaken to explore the influence o...

Journal: :Stroke 2013
Nobukazu Miyamoto Takakuni Maki Loc-Duyen D Pham Kazuhide Hayakawa Ji Hae Seo Emiri T Mandeville Joseph B Mandeville Kyu-Won Kim Eng H Lo Ken Arai

BACKGROUND AND PURPOSE White matter injury caused by cerebral hypoperfusion may contribute to the pathophysiology of vascular dementia and stroke, but the underlying mechanisms remain to be fully defined. Here, we test the hypothesis that oxidative stress interferes with endogenous white matter repair by disrupting renewal processes mediated by oligodendrocyte precursor cells (OPCs). METHODS ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید