نتایج جستجو برای: chronic allograft nephropathy

تعداد نتایج: 532196  

Journal: :Clinical journal of the American Society of Nephrology : CJASN 2011
Anja De Rycke Daan Dierickx Dirk R Kuypers

Tacrolimus has become an important cornerstone in the prevention of rejection after kidney transplantation. However, its use has been complicated by several side effects, including chronic allograft nephropathy, diabetes mellitus, arterial hypertension, and neurotoxicity. Tacrolimus-induced neutropenia is a less recognized, but potentially harmful complication. Three patients with severe neutro...

2012
Qiquan Sun Song Jiang Xue Li Xianghua Huang Kenan Xie Dongrui Cheng Jinsong Chen Shuming Ji Jiqiu Wen Mingchao Zhang Caihong Zeng Zhihong Liu

Post-transplant proteinuria is a common complication after renal transplantation; it is associated with reduced graft and recipient survival. However, the prevalence of histological causes has been reported with considerable variation. A clinico-pathological re-evaluation of post-transplant proteinuria is necessary, especially after dismissal of the term "chronic allograft nephropathy," which h...

Journal: :Clinical journal of the American Society of Nephrology : CJASN 2007
Enver Akalin Rajani Dinavahi Steven Dikman Graciela de Boccardo Rex Friedlander Bernd Schroppel Vinita Sehgal Jonathan S Bromberg Peter Heeger Barbara Murphy

BACKGROUND AND OBJECTIVES Transplant glomerulopathy (TGP) has been proposed to be a component of chronic antibody-mediated rejection (AMR). We have studied 36 patients with TGP and 51 patients with chronic allograft nephropathy (CAN) but without TGP for C4d staining and donor-specific anti-HLA antibodies (DSA) to investigate the alloantibody-mediated mechanisms. DESIGN, SETTING, PARTICIPANTS,...

2011
Ping-Nam Wong Alice N. H. Chan Kin-Yee Lo Yuk-Yi Wong Siu-Ka Mak Andrew K. M. Wong

Intratubular calcification is a common finding in renal allografts. However, possible harmful effect of this calcification is not well recognized, and allograft failure purely due to this condition has not been reported. We report a kidney transplant recipient who suffered from severe secondary hyperparathyroidism and unexplained early allograft failure. A diagnosis of acute phosphate nephropat...

2013
Ankit Mahendra Ivan Peyron Cécile Dollinger Laurent Gilardin Meenu Sharma Bharath Wootla Séverine Padiolleau-Lefevre Alain Friboulet Didier Boquet Christophe Legendre Srinivas V. Kaveri Olivier Thaunat Sébastien Lacroix-Desmazes

Catalytic antibodies are immunoglobulins endowed with enzymatic activity. Catalytic IgG has been reported in several human autoimmune and inflammatory diseases. In particular, low levels of catalytic IgG have been proposed as a prognostic marker for chronic allograft rejection in patients undergoing kidney transplant. Kidney allograft is a treatment of choice for patients with end-stage renal f...

2016
Sarat Kuppachi Deepkamal Kaur Danniele G. Holanda Christie P. Thomas

BK virus (BKV) is a non-enveloped DNA virus of the polyomaviridae family that causes an interstitial nephritis in immunosuppressed patients. BKV nephropathy is now a leading cause of chronic kidney disease and early allograft failure following kidney transplantation. It is also known to cause renal disease with a progressive decline in kidney function in non-renal solid organ transplant (NRSOT)...

Journal: :Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 2013
Hassan Nikoueinejad Alireza Soleimani Abbas Mirshafiey Aliakbar Amirzargar Abdolfattah Sarrafnejad Ideh Kamkar Behzad Einollahi

One way to overcome chronic allograft nephropathy induced by calcineurin inhibitors in immunosuppression protocols for organ transplants is to replace such inhibitors with mammalian target of rapamycin inhibitors, which are not clinically nephrotoxic because they have better renal function. If patients tolerate replacement, there could be a clear preference for mammalian target of rapamycin inh...

Journal: :Journal of the American Society of Nephrology : JASN 2001
P Iñigo J M Campistol S Lario C Piera B Campos M Bescós F Oppenheimer F Rivera

Hypertension and hyperfiltration are two important risk factors for the development of chronic allograft nephropathy. Transforming growth factor-beta(1) (TGF-beta(1)) is the main cytokine involved in the fibrotic process that is involved in chronic rejection. Angiotensin II upregulates TGF-beta(1) production. Angiotensin II receptor antagonists therefore could not only control BP but also reduc...

2013
Christoph Daniel Regina Vogelbacher Andrea Stief Christina Grigo Christian Hugo

We recently identified Thrombospondin-2 (TSP-2) as a regulator of matrix remodelling and inflammation in experimental kidney disease by using TSP-2 null mice and successfully proved TSP-2 overexpression as a therapeutic concept in a short term glomerulonephritis model in the rat. In this current study, we investigated if long-term TSP-2 overexpression is also capable to ameliorate the progressi...

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