To define further the clinical importance of cytogenetic analysis in acute lymphoblastic leukaemia (ALL) a prospective study was performed on 139 unselected children. Analyses were considered adequate in 104, of whom 35 were normal and 69 had clonal abnormalities. Abnormalities were categorised according to banded chromosome analysis as well as chromosome count. Karyotypes were correlated with ...

A genome-wide scan was performed to detect quantitative trait loci (QTL) for resistance to the gastrointestinal nematode Haemonchus contortus in a double backcross population of Red Maasai and Dorper sheep. The mapping population comprised six sire families, with 1026 lambs in total. The lambs were artificially challenged with H. contortus at about 6.5 months of age, and nine phenotypes were me...

(Figure 1). In invertebrates, X-linked numerator and autosomally encoded denominator genes encode proteins which differ in relative abundance in XX versus XY or XO cells. A 2-fold difference in stoichiometry signals the production of master regulatory proteins, XO-lethal in Barbara Panning*‡ and Rudolf Jaenisch*† *Whitehead Institute for Biomedical Research Cambridge, Massachusetts 02142 †Depar...

Background: Constitutional chromosome abnormalities are among the major contributors to the genetic causes of reproductive disorders. Despite all of worldwide efforts have been made so far, the prognosis for mosaic X chromosome aberration below 30% of unemployed has yet to be established. The purpose of this study was to assess the quantity and quiddity of chromosomal aberrations that may negat...

background: cytogenetic analysis, y-chromosome microdeletion screening, fish techniques and other genetic methods have helped in finding the causes of infertility in azoospermic or severe oligoazoospermic cases in the last decade. objective: in the present study, we characterized an abnormal y-chromosome, detected as a mosaic in an azoospermic male ascertained for infertility. materials and met...

Klinefelter syndrome (KS), with an incidence of 1 in 600 male newborns, is the most common type of X chromosome aneuploidy. Individuals with KS are characterized by tall stature, decreased secondary sexual characteristics, small testicles, gynecomastia, and infertility. About 80% of patients have the karyotype 47,XXY [1]. An extra X chromosome as a sole acquired abnormality has also been report...

background and objective: candidiasis is a common opportunistic infection in hiv-infected patients. the spectrum of candida infection is diverse, starting from asymptomatic colonization to pathogenicforms. the low absolute cd4+ t-lymphocyte count has traditionally been cited as the greatest risk factor for the development of oropharyngeal candidiasis and current guidelines suggest increased ris...