used for thyroid disease could generate a chromosomal aberration, particularly (t 9,22) (q34 q11) developing, with a long latency, CML or in this case Ph+ ALL. Although the risk of leukemia after 131I exposure cannot be considered a contraindication to 131I therapy, strict hematologic follow-up of patients submitted to 131I treatment is recommended. Retrospective analysis of 131I exposure in la...

Note Chromosomal deletions are among the most common genetic events observed in hematologic malignancies; loss of genetic materiel is regarded as a hallmark of putative tumor suppressor gene localization. Deletions 13q occurs in lymphoid neoplasias: see del(13q) in non-Hodgkin's lymphoma and del(13q) in chronic lymphoproliferative diseases. In myeloid disorders, the most frequently reported del...

Cytogenetic studies started during the early 1940’s with the studies of Karl Sax on the induction of chromosomal aberration in Tradescantia microspores by X-rays and later it has been applied in the study of human chromosomes. Generally the cytogenetic techniques are useful to estimate radiation doses received due to external radiation exposure it is difficult to estimate radiation doses except...

The genotoxic effects of occupational exposure to ionizing and non-ionizing radiation were investigated in 25 physicians and nurses working in hospitals and in 20 individuals working at radio-relay stations. Examination was conducted by chromosome aberration analysis of peripheral blood lymphocytes. The data showed that total number of chromosome aberrations in people exposed to ionizing and ra...

The patients evaluated in this study were classified into three groups of severe, moderate, and mild according to the severity of exposure to sulfur mustard. We evaluated the Immunological and Cytogenetical status of the patients after eight years of their exposure to sulfur mustard. The investigations revealed that the number of neutrophils, lymphocytes and monocytes in the patients with sever...

Chromosomal aberrations are associated with increased cancer risk in adults. Previously, we demonstrated that stable aberrations involving chromosomes 1-6 in cord blood are associated with prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) measured in air and are disproportionate to genomic content. We now examine whether the association with air PAHs is chromosome-specific and extend...