Blood–brain barrier (BBB) permeability is an essential phenomena when considering the treatment of neurological disorders as well in case central nervous system (CNS) adverse effects caused by peripherally acting drugs. The presented work contains statistical analyses and correlation assessment analyzed group active pharmaceutical ingredients (APIs) with their BBB-permeability data collected fr...

The properties relevant to pharmacokinetics and pharmacodynamics of four series of synthesized s-triazine derivatives have been studied by Quantitative structure-retention relationship (QSRR) approach. The chromatographic behavior of these compounds was investigated by using reversed-phase high performance thin-layer chromatography (RP-HPTLC). Chromatographic retention (RM0) was correlated with...

        A simple, reproducible and rapid gas chromatographic method for precise determination of valproic acid (VPA) in human plasma has been developed. Total time for sample preparation and GC analysis is less than 45 min. After plasma protein precipitation, VPA was extracted into chloroform with suitable recovery. By using Stabilwax®<span styl...

PRYER, K. M., D. M. BRITTON, and J. MCNEILL. 1983. A numerical analysis of chromatographic profiles in North American taxa of the fern genus Gymnocnrpium. Can. J. Bot. 61: 2592-2602. As part of a systematic investigation of the genus Gyrnrzocnrpiiirn in North America, a survey of chromatographic profiles in species and hybrids of the genus was initiated. It was established through cluster analy...

Quantitative high-performance liquid chromatographic analysis of perbenzoylated sphingolipids has been used to study the correlations of body chemistry to clinical phenomena. Plasma sphingolipids were isolated from 32 Gaucher (beta-glucosidase deficiency) and six Fabry (alpha-galactosidase deficiency) patients by solvent partition and chromatographic separation on silicic acid columns. Plasma s...