In this study the effect of the alkylating agent, sulfur mustard, on calf thymus chromatin was investigated using UV/Vis spectroscopy, gel electrophoresis and thermal denaturation techniques. The results show that treatment of isolated chromatin with sulfur mustard releases histones from the core particles but does not affect histone H I and nonhistone chromosomal proteins. The content of ...

Purpose of the present work is to investigate the mutagenic effects of ionizing radiations (gamma rays) on Brassica campestris L. accession no IC363713. Homogeneous seeds of Brassica were irradiated at four doses of gamma rays i.e. 150 Gy, 300 Gy, 450 Gy and 600 Gy by the gamma-chamber type Co at the dose rate of 2 second/Gy. During microsporogenesis, meiotic analysis of young floral buds was c...

Members of the PIAS (for protein inhibitor of activated STAT) family play critical roles in modulating the activity of a variety of transcriptional regulators. Zimp10, a novel PIAS-like protein, is a transcriptional coregulator and may be involved in the modification of chromatin through interactions with the SWI/SNF chromatin-remodeling complexes. Here, we investigate the biological role of Zi...

anatomy of the root canal system always effects endodontic treatment outcome. mandibular premolar teeth show extreme variations in root canal morphology. first premolars usually exhibit basic one root and one canal anatomy. the occurrence of three roots in mandibular first premolar has not been commonly reported in literature. this article reports a case of successful nonsurgical endodontic man...

background: recurrent abortion is a difficult medical problem happening in about 1-2% of fertile women. most spontaneous miscarriages which happen in the first and second trimesters are caused by chromosomal abnormalities. objective: the present study tries to find the rate of chromosomal abnormalities in couples with recurrent pregnancy loss. materials and methods: in total 165 couples were re...

The nuclear pore complex is a multiprotein comprising approximately 30 different proteins called nucleoporins (Nups). Recent studies in yeast, animals, and plants have shown that the Nups bind to chromatin interact with transcription factors, chromatin-remodeling histone-modifying enzymes, structural proteins, including CCCTC-binding factor cohesin. These findings suggest provide subnuclear pla...

Background During mammalian spermatogenesis unique and dynamic epigenetic events occur leading to chromatin condensation. Through these events, histone demethylases such as JMJD1A play important roles in compaction of sperm chromatin, due to regulation of histone methylation dynamics and alteration of chromatin structure. As �histone methylation� is one of the best-characterized modifications i...

Background: Selection of human spermatozoa prior to assisted reproduction is currently based on motility and morphology. Recently, Zeta method has been introduced for normal sperm selection based on sperm surface charges. In addition, one of the features of apoptosis is the externalization of phosphatidylserine (PS), which are normally present on the inner leaflet of the sperm plasma membrane. ...

A growing body of studies suggests that neurological and mental abnormalities foster conformity to norms of rationality that are widely endorsed in economics and psychology, whereas normality stands in the way of rationality thus defined. Here, we outline the main findings of these studies, discuss their implications for experimental design, and consider how 'sane' some benchmarks of rationalit...

Method of Controlling Epistaxis P. V. Wadsworth, F.R.C,S ................. 506 Treating Fibrositis I. H. J. Boume, M.B ..................... 506 Advisory Councils on Industrial Health S. A. Underwood, M.B., D.I.H ............. 506 Consultants' Salaries J. M. Brindle, F.F.R., and P. J. Briggs, M.R.C.S ,.. .... 507 Self-certification F. W. B. Breakey, M.B ................... 507 Mum's Not the Wor...