نتایج جستجو برای: cholinesterase enzyme inhibitory

تعداد نتایج: 362322  

Journal: :The Journal of pharmacology and experimental therapeutics 1954
E M ROBINSON R BECK B P McNAMARA L J EDBERG J H WILLS

In a previous report (McNamara et at., 1954) it was noted that spinal reflexes could be abolished reversibly by anticholinesterase compounds. When the ammals were sacrificed after return of the reflex activity, some were found to have considerable cholinesterase in their spinal cords and in other areas of the body; in other animals the enzyme was apparently absent. No determinations of acetylch...

Journal: :Clinical chemistry 1987
R T Evans A Walker K M Bowness

We report results of an investigation into the proficiency of cholinesterase (EC 3.1.1.8) phenotying, assessed in 13 laboratories between 1983 and 1986. Thirty-two specimens of serum were distributed for analysis: two, each in duplicate, from the eight genotypes that can be recognized by differential enzyme inhibitor numbers. The accuracy of genotype ascription was markedly improved over that o...

2015
Miroslav Pohanka

Acetyl cholinesterase (AChE) and butyryl cholinesterase (BChE) are two known enzymes in the body with ability to hydrolyze acetylcholine. While AChE plays crucial role in acetylcholine mediated neurotransmission, BChE is secreted from livers to plasma and biological role of the enzyme is not fully understood [1]. The both cholinesterases are very sensitive to inhibition by nerve agents such as ...

2017
Zahra Amri Asma Ghorbel Mouna Turki Férièle Messadi Akrout Fatma Ayadi Abdelfateh Elfeki Mohamed Hammami

BACKGROUND To investigate beneficial effects of Pomegranate seeds oil (PSO), leaves (PL), juice (PJ) and (PP) on brain cholinesterase activity, brain oxidative stress and lipid profile in high-fat-high fructose diet (HFD) induced-obese rat. METHODS In vitro and in vivo cholinesterase activity, brain oxidative status, body and brain weight and plasma lipid profile were measured in control rats...

2017
Shu Peng Yu-Chen Pan Yaling Wang Zhe Xu Chao Chen Dan Ding Yongjian Wang Dong-Sheng Guo

The introduction of controlled self-assembly into living organisms opens up desired biomedical applications in wide areas including bioimaging/assays, drug delivery, and tissue engineering. Besides the enzyme-activated examples reported before, controlled self-assembly under integrated stimuli, especially in the form of sequential input, is unprecedented and ultimately challenging. This study r...

Journal: :Clinical chemistry 1977
H K O'Farrell S K Chattopadhyay H D Brown

Cholinesterase activity in human serum was measured calorimetrically and compared to values obtained with the spectrophotometric method of Rappaport et al. [Clin. Chim. Acta 4, 227 (1959)]. The response of the calorimeter upon mixing serum with acetylcholine corresponded to the cholinesterase activity of the serum, the thermogram peak height being linearly related to enzyme activity at serum di...

Journal: :Ecotoxicology 2010
Víctor M Cobos Miguel A Mora Griselda Escalona Sophie Calme Juan Jiménez

Cholinesterase (ChE) activity in birds is subject to interspecific and intraspecific species variations. Factors that influence enzyme activity have to be taken into account in order to obtain an accurate estimation of cholinesterase inhibition due to pesticide exposure in wild birds. This study evaluates variation of plasma cholinesterase activity in clay-colored robin (Turdus grayi) in relati...

2013
Vijay Kumar Singh Yogesh Kumar Verma

Fenvalerate is a synthetic pyrethroid , widely used due to its high effective and low mammalian toxicity. Fenvalerate, dose equivalent to LD25 was administered orally for acute exposure and dose equivalent to LD5 for subchronic & chronic exposure to Wistar rats. Toxic effect of Fenvalerate observed in serum Lypase, alanine aminotransferase (ALT), aspartate aminotransferase (AST), Cholinesterase...

Journal: :British journal of anaesthesia 1995
I Sockalingam D W Green

We report a case of prolonged neuromuscular block after administration of mivacurium 0.2 mg kg-1 to a 16-yr-old patient where the duration of block was 2.5 h. The interesting points in this case were that the patient had homozygous atypical plasma cholinesterase deficiency (both parents had a normal phenotype) following liver transplantation. Investigations showed low plasma cholinesterase acti...

2015
I.A. Owokotomo O. Ekundayo T.G. Abayomi A.V. Chukwuka

The chemical inhibition of acetyl-cholinesterase (AChE) is a potent strategy for addressing signal related neuropathology and natural products are potential sources of compounds with such properties. Essential oil extracts from leaf, seed, stem and rhizome of four medicinal plants [Aframomum melegueta K. Schum, Crassocephalum crepidioides (Benth S. More), Monodora myristica (Gaertn.), and Ocimu...

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