نتایج جستجو برای: cholesteryl ester transfer protein

تعداد نتایج: 1521886  

Journal: :Journal of lipid research 2010
Mollie Ranalletta Kathleen K Bierilo Ying Chen Denise Milot Qing Chen Elaine Tung Caroline Houde Nadine H Elowe Margarita Garcia-Calvo Gene Porter Suzanne Eveland Betsy Frantz-Wattley Mike Kavana George Addona Peter Sinclair Carl Sparrow Edward A O'Neill Ken S Koblan Ayesha Sitlani Brian Hubbard Timothy S Fisher

Cholesteryl ester transfer protein (CETP) has been identified as a novel target for increasing HDL cholesterol levels. In this report, we describe the biochemical characterization of anacetrapib, a potent inhibitor of CETP. To better understand the mechanism by which anacetrapib inhibits CETP activity, its biochemical properties were compared with CETP inhibitors from distinct structural classe...

Journal: :The Journal of clinical investigation 1997
L A Woollett D K Spady

These studies were undertaken to determine the kinetic characteristics of high density lipoprotein (HDL) apo AI and cholesteryl ester transport in the hamster in vivo. Saturable HDL apo AI transport was demonstrated in the kidneys, adrenal glands, and liver. Saturable HDL cholesteryl ester transport was highest in the adrenal glands and liver. In the liver and adrenal glands, maximal transport ...

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