Objective: To determine the relative frequency of various parts of temporal bone eroded by cholesteatoma. Place and duration of study: This was a combined study conducted in the ENT Departments of Postgraduate Medical Institute, Hayatabad Medical Complex, Peshawar, and Lady Reading Hospital Peshawar. The study took place over a period of 5 years from January1, 2007 to December 31, 2011. Sample ...

HYPOTHESIS This study aimed to analyze the localization and distribution of vessels and of these angiogenic growth factors: basic fibroblast growth factor (FGF-2), transforming growth factor-alpha (TGF-alpha), transforming growth factor-beta1 (TGF-beta1), and vascular endothelial growth factor (VEGF) in middle ear cholesteatoma in comparison with normal middle ear mucosa and auditory meatal ski...

OBJECTIVE A cholesteatoma is a mass of keratinising epithelium in the middle ear. It is a rare disorder that is associated with significant morbidity, and its causative risk factors are poorly understood; on a global scale, up to a million people are affected by this each year. We have conducted a systematic literature review to identify reports about the heritability of cholesteatoma or any co...

OBJECTIVE To evaluate the long-term outcome of atticotomy (AT) surgery for cholesteatoma in children. STUDY DESIGN Case series, retrospective chart review. SETTING General otology practice in a teaching hospital. PATIENTS Fifty-three children aged 5 to 16 years old with cholesteatoma limited to the attic and middle ear who underwent AT between the years 1979 to 1994. INTERVENTIONS AT co...

Surgical treatment of petrous cholesteatoma that involves the petrous pyramid and extends beyond the internal auditory canal is often difficult because of the site and extent of the cholesteatoma. Various problems pertaining to the operation are discussed from our experience with fourteen patients who underwent surgery in our hospital. When accompanied with otorrhea, the middle ear was eradicat...

HYPOTHESIS We designed a study to determine the role of mastoid mucosal biofilm in chronic otitis media (COM). BACKGROUND Biofilm formation has been found in several chronic airway infections. COM is associated with chronic, recalcitrant infection of the mastoid mucosa, and surgery often is required. METHODS COM patients were divided into 2 groups: one with chronic suppurative otitis media ...

OBJECTIVE This study aimed to analyze the clinical features of patients who underwent surgery for secondary acquired cholesteatoma (SAC). MATERIALS AND METHODS The subjects were 30 patients who underwent surgery for SAC in 30 ears. We investigated the age distribution, sex, tympanic membrane (TM) findings, temporal bone pneumatization, morphology of TM epidermis invasion, extent of cholesteat...

OBJECTIVES To image cholesteatoma using optical coherence tomography (OCT) and correlate the results with clinical findings and conventional observations obtained using binocular microscopy and histology. OCT is a high-resolution optical imaging modality that generates cross-sectional images of turbid media, such as tissue with resolution approaching that of light microscopy. OCT relies on intr...

BACKGROUND AND PURPOSE Previous reports have shown that DWI is useful in detecting cholesteatoma. SS-EPI is the most widely used DWI technique. However, SS-EPI may have susceptibility artifacts due to field inhomogeneity in the imaging of the temporal bone region. Our purpose was to prospectively evaluate the advantage of MS-EPI for the diagnosis of middle ear cholesteatoma by comparing it with...

INTRODUCTION In the surgical management of cholesteatoma, one can opt for a closed technique (simple mastoidectomy) or open surgery (radical mastoidectomy). Open mastoidectomy with reconstruction of the posterior wall and the middle ear in a single surgery combines the advantages of both techniques, namely, adequate surgical exposure, eradication of cholesteatoma, and anatomical reconstruction ...