Chlorpromazine and thioridazine are phenothiazines employed in the treatment of psychosis. These agents inhibited the respiration of clinical isolates of Mycobacterium tuberculosis resistant to streptomycin, rifampin, isoniazid, ethambutol and/or pyrazinamid, all first line drugs. Since any adverse reaction to thioridazine is generally less severe than to chlorpromazine, the possibility is attr...

Chlorpromazine-induced agranulocytosis is an uncommon disorder associated with a high frequency of fatality. We describe two patients with chlorpromazine-induced granulocytosis in whom granulocyte colony stimulating factor (G-CSF) administration enhanced the speed of neutrophil recovery. No toxicity was noted with G-CSF and both patients made a successful recovery. We propose there is a role fo...

Struijs PAPAA, Arola H, Assendelft WJJ, et al. Orthotic devices for the treatment of tennis elbow. The Cochrane Database of Systematic Reviews 2002, Issue 1. Art. No.: CD001821. DOI: 10.1002/14651858.CD001821. Struijs PA, Kerkhoffs GM, Assendelft WJ, et al. Conservative treatment of lateral epicondylitis: brace versus physical therapy or a combination of both-a randomized clinical trial. Americ...

A prospective double blind study was conducted to evaluate the role of E.C.T. in schizophrenia. Before the start of the trial patients were kept on chlorpromazine in adequate dosage for 30 days. Those who showed fifty percent or more improvement during this period were excluded. All patients were given eight modified or simulated E.C.T.s. The patients were followed up for one month. E.C.T. did ...

Chlorpromazine causes precipitation both of the glycoprotein and protein components of bile in vitro. The reaction depends on an electrostatic interaction between the negatively charged carboxyl groups on the bile components and the positively charged amine groups on the drug molecules in solution. The optimum conditions for the interaction between chiorprom. azine and bile components have been...

Chlorpromazine (CPZ) and three other phenothiazines and the structurally related antidepressant drugs imipramine and amitriptyline were found to depress human neutrophil chemotactic responsiveness. A 7 X 10(-6)M solution of CPZ inhibited chemotaxis, whereas concentrations of the other tested drugs 10 to 1,000 times greater than this were needed to inhibit chemotaxis. This effect of CPZ could no...

The role of dopaminergic and cholinergic functions in the genesis of an electroretinogram is unclear. The present study was carried out to elucidate the direct actions of some psychotropic drugs in isolated rabbit retinas. Methamphetamine and apomorphine decreased dose-dependently the b-wave amplitude at a dose of 10(-7)-10(-5) g/ml. On the other hand, chlorpromazine and haloperidol, as well as...