The cardiovascular effects of phenothiazine derivatives in general and chlorpromazine in particular are quite complex (4·6, 1], 13, 14, 17) because such drugs produce direct effects on the heart and blood vessels, and also indirect ones through actions on C.N.S. and autonomic reflexes. Hypotension most commonly seen, is pnmirily due to inhibition of cetrally mediated pressor reflexes, but perip...

A number of antipsychotic drugs have been available in the US, beginning in the early 1950s with chlorpromazine, and these drugs have proven to be immensely useful in the treatment of various psychotic illnesses, in particular schizophrenia. Several of these drugs are available in parenteral form, e.g., haloperidol and chlorpromazine, for intramuscular (IM) use. Many clinicians have found these...

IN an endeavour to potentiate the effect of pethidine and scopolamine premedication, the drugs chlorpromazine and hydergine were investigated, particularly in regard to their effects on the autonomic nervous system. A comparison was made between three comparable series of patients. One series acted as a control and the other series had chlorpromazine and hydergine respectively. Changes in pulse...

The effects of three phenothiazines, chlorpromazine (CPZ), chlorpromazine sulfoxide (CPZ-O), and 74iydroxychlor promazine (7-OH-CPZ), on the growth of B-16 and HardingPassey mouse melanomas were investigated. CPZ and 7-OH-CPZ both inhibited tumor growth, but CPZ-O did not. The melanoma tyrosinase was activated by CPZ both in vivo and in vitro. There was no significant effect of CPZ on the succi...

In view of the possibility of human error or changes in our knowledge due to continued research, neither the author nor The University of Iowa nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect accurate or complete, and they are not responsible for any errors or omissions or for the results ...

A simple, rapid, precise, and accurate method is described for the simultaneous and quantitative determination of conjugated and unconjugated chlorpromazine metabolites in urine. It depends on reduction of sulfoxides to sulfides, and oxidation of sulfides to ion radicals in a solution of Fe-I-a (lO-N) in l8N H2S04.Absorbance is measured at 422, 530, 565, and 700 nm, and concentration of metabol...

The study of shape-transformed human erythrocytes is of hematological interest since several clinical conditions are associated with erythrocyte shape changes. Using the micropipette technique, we examined the rheological behaviors of echinocytes induced by sodium salicylate or ATP depletion and of stomatocytes induced by chlorpromazine. Both the discocyte-echinocyte and discocyte-stomatocyte t...

Recent studies have demonstrated that psychotropic drugs such as reserpine and chlorpromazine cause a significant increase in plasma human prolactin (hPRL) levels, frequently inducing galactorrhea (Frantz et al., 1972). Chlorpromazine is now commonly used as a means of stimulating hPRL secretion in man (Friesen et al., 1972; Turkington, 1972). Borenstein et al. (1968) first reported that galact...

Serum separation gels are problematic in therapeutic drug monitoring because they adsorb some of the target drugs; however, adsorptive properties drugs that cause clinical intoxication remain unelucidated. Drug adsorption to separators results a decrease observed blood levels, which may lead uncertain assessments toxicology. Therefore, this study aimed clarify effects four brands collection tub...