Introduction Chloride is the most important anion associated with sodium in the extra cellular fluid with a normal concentration ranging from 96 to 106 (1). The complete interpretation of acid-base disorders is impossible without knowing the serum chloride concentration (2). In the process of quantitative acid-base analysis, plasma pH is determined by three independent variables: pCO2, total co...

The Baylis-Hillman reactions of various aryl aldehydes with methyl vinyl ketone at temperatures below -20C using Lewis acids such as titanium (IV) chloride, boron (III) chloride or zirconium (IV) chloride in the presence of a catalytic amount of selected amines used as a Lewis bases afford the chlorinated compounds 1 as the major product in very high yields. Acrylonitrile can also undergo the s...

1. Micropuncture studies of chloride and bicarbonate absorption in the proximal tubule under free flow conditions were performed during exposure to 12% COz in air, during recovery from COz on a low chloride diet with and without concomitant sodium restriction, and during re-exposure to 12% COz in air with continuing chloride restriction. 2. After 3 hr of exposure to COz there was a significant ...

Due to genetic defects in apical membrane chloride channels, the cystic fibrosis (CF) intestine does not secrete chloride normally. Depressed chloride secretion leaves CF intestinal absorptive processes unopposed, which results in net fluid hyperabsorption, dehydration of intestinal contents, and a propensity to inspissated intestinal obstruction. This theory is based primarily on in vitro stud...

Chloride influx through GABA-gated chloride channels, the primary mechanism by which neural activity is inhibited in the adult mammalian brain, depends on chloride gradients established by the potassium chloride cotransporter KCC2. We used a genetic screen to identify genes important for inhibition of the hermaphrodite-specific motor neurons (HSNs) that stimulate Caenorhabditis elegans egg-layi...