Abstract Chlamydia trachomatisis the main cause of sexually transmitted disease and preventable blindness worldwide. In both animals humans, Chlamydiaspp. infect not only female reproductive tract (FRT), but also gastrointestinal (GIT), where it persists for long periods, without causing obvious pathology. murine model, following FRT infection, Chlamydiaspreads to GIT in stages relies on carria...

INTRODUCTION National guidelines recommend opportunistic chlamydia screening of sexually active 16- to 29-year-olds and encourage retesting 3-12 months after a diagnosed chlamydia (Chlamydia trachomatis) infection. We assessed chlamydia testing patterns at five Australian family planning clinics (FPCs). METHODS Using routine clinic data from 16- to 29-year-olds, we calculated chlamydia testin...

INTRODUCTION The primary objective is to determine the prevalence of Chlamydia trachomatis infection among 200 women seeking termination of pregnancy (TOP) at National University Hospital (NUH), Singapore. The secondary objective is to determine the existence of high-risk sexual behaviours/practices among these women. MATERIALS AND METHODS Two endocervical swabs were taken from these women; o...

BACKGROUND Cervical chlamydia infection poses high risk of pregnancy complications and neonatal infection. Reference methods for the detection of chlamydia infection are not available for routine use in developing countries. Point-of-care (POC) tests can bridge this gap. This study evaluated Cortez Onestep Chlamydia Rapicard™ insta test for the detection of Chlamydia trachomatis in pregnant wom...

Epithelial cells lining the murine genital tract act as sentinels for microbial infection, play a major role in the initiation of the early inflammatory response, and can secrete factors that modulate the adaptive immune response when infected with Chlamydia. C. muridarum-infected murine oviduct epithelial cells secrete the inflammatory cytokines IL-6 and GM-CSF in a TLR2-dependent manner. Furt...

Chlamydia trachomatis is a pathogen responsible for a prevalent sexually transmitted disease. It is also the most common cause of infectious blindness in the developing world. We performed a loss-of-function genetic screen in human haploid cells to identify host factors important in C. trachomatis L2 infection. We identified and confirmed B3GAT3, B4GALT7, and SLC35B2, which encode glucuronosylt...

Chlamydia trachomatis is among the most prevalent of sexually transmitted diseases. While Chlamydia infection is a reportable event and screening has increased over time, enhanced surveillance has not resulted in a reduction in the rate of infections, and Chlamydia infections frequently recur. The development of a preventative vaccine for Chlamydia may be the only effective approach for reducin...

Chlamydia trachomatis is a Gram-negative obligate intracellular bacterial pathogen. It is associated with significant human illness, including preventable blindness, reactive arthritis. Furthermore, it is the most common agent of bacterial sexually transmitted diseases with potentially serious sequel in women that include pelvic inflammatory disease, ectopic pregnancy and sterility. As an oblig...

Both human herpes viruses and Chlamydia are highly prevalent in the human population and are detected together in different human disorders. Here, we demonstrate that co-infection with human herpes virus 6 (HHV6) interferes with the developmental cycle of C. trachomatis and induces persistence. Induction of chlamydial persistence by HHV6 is independent of productive virus infection, but require...