This study was aimed evaluation, Zinc sulfide-chitosan nanoparticles (ZnS-chitosan NPs) as an antibacterial agent. The of were synthesized using a single-step colloidal process. Different factors optimized, which included pH, temperature, reaction time, concentrations chitosan and chloride .The optimal conditions achieved at pH 7, temperature 60℃, time 60min, with 0.04 mg/ml chloride, 2.5 ml 0....

Introduction: Clinical application of platinum-based anticancer drugs is largely limited by severe toxicity. Drug delivery systems are highly desired for improving the efficacy and applicability of these drugs. This study describes an alternative strategy for the delivery of a new synthesized Pt(II) complex (bipyridin morpholin dithio carbomate Pt(II) nitrate) by its encapsulating in the Beta-C...

Chitosan polyplexes containing plasmid DNA (pDNA) have significant potential for pulmonary gene delivery applications. However, prior to using chitosan/pDNA polyplexes (CSpp) in clinical applications, their potential cytotoxicity needs to be investigated. In this study, we formulated 200-400 nm CSpp with amine to phosphate (N/P) ratios that ranged from 1 to 100. We compared two types of plasmid...

The present study is aimed at the overall improvement in the efficacy, reduced toxicity and enhancement of therapeutic index of cisplatin. Nanocapsules of cisplatin containing ethylcellulose have been prepared using solvent evaporation technique under ambient conditions. The prepared nanocapsules were used for controlled drug release of anticancer agents with gold and iron oxide nanoparticles. ...

Slow release testosterone-loaded nanocapsules in alginate, biodegradable hydropolymer, were prepared by in situ nanoemulsion-polymer crosslinking approach. Different formulations varying in the drug loading solvent phase were prepared. Four different drug-loading solvents were assayed and the food grade hexane provided nanocapsules testosterone load of 30%. Testosterone loading was confirmed by...

For the development of effective drug carriers, nanocapsules that respond to micro-environmental changes including a decrease in pH and a reductive environment were prepared by the stabilization of polymer vesicles formed from head-tail type polycations, composed of a polyamidoamine dendron head and a poly(L-lysine) tail (PAMAM dendron-PLL), through the introduction of disulfide bonds between t...

Lipid nanocapsules (LNCs) have proven their efficacy in delivering different drugs to various cancers, but no studies yet described uptake mechanisms, paclitaxel (PTX) delivery or resulting cytotoxicity towards breast cancer cells. Herein, we report results concerning cellular of LNCs and PTX-loaded (LNCs-PTX) on the three cell lines MCF-7, MDA-MB-231 MDA-MB-468. LNCs-PTX sizes 50 ± 2 nm, 90 3 ...