نتایج جستجو برای: children thalassemia
تعداد نتایج: 482727 فیلتر نتایج به سال:
Sixty thalassemia patients (median age, 7 years; range, 1-37) underwent allogeneic hematopoietic stem cell transplantation (HSCT) after a preparation combining thiotepa, treosulfan, and fludarabine. Before HSCT, 27 children were assigned to risk class 1 of the Pesaro classification, 17 to class 2, and 4 to class 3; 12 patients were adults. Twenty patients were transplanted from an HLA-identical...
background we aimed to investigate the frequency of celiac disease in children with β-thalassemia major (b-tm) in shiraz, southern iran. materials and methods in this study, the prevalence of celiac disease in children with b-tm was evaluated. children with btm were screened for celiac disease by ant-tissue transglutaminase (anti-ttg) iga antibody, iga level and anti-ttg igg. a total of 1500 sc...
Background: Patients with beta-thalassemia present with severe anemia requiring regular red blood cell transfusions. This can lead to iron overload and its related complications including disorders of the endocrine systems. The aim of this work was to study parathyroid function in children with beta-thalassemia major in correlation with iron load. Methods: 60 patients with beta-thalassemia majo...
Thalassemia Major is common in India. Every year, about 10000 new patients are diagnosed in India. Treatment requires lifelong monthly transfusions, iron chelation therapy, and other care. A large number of children die before 20 years of age, even before 10 years of age in many rural areas. Average cost of care is Rs. 15,00,000 (fifteen lac) by age 15. Cost goes up with increasing age of child...
In Yemen, the prevalence of sickle cell trait and β-thalassemia trait are high. The aim of this premarital program is to identify sickle cell and thalassemia carrier couples in Yemen before completing marriages proposal, in order to prevent affected birth. This can be achieved by applying a low-cost premarital screening program using simple blood tests compatible with the limited health resourc...
Due to improvements in transfusion therapy in beta-thalassemia major patients, transfusional hemosiderosis has now become the major cause of late morbidity and mortality in them. In India and other developing countries, iron chelation therapy is still not strictly adhered to in these children, mostly due to financial constraints. An orally effective and cheap iron chelator is the need of the ho...
β – thalassemia major is a chronic inherited blood disorder requiring lifelong treatment including transfusion, putting tremendous burden on caregivers of the affected children. Aims were to measure care, prevalence and severity depression anxiety, their association with various socio-demographic illness related factors in children major. A cross-sectional study was conducted 100 suffering from...
BACKGROUND Thalassemic disorders are the most prevalent monogenic hereditary diseases around the world caused by decreased and altered synthesis or agenesis in one or more globin chains. Families who have a child with thalassemia major face a myriad of significant problems. Hormozgan province ranks second with thalassemic patients in Iran. Therefore, current research is aimed to analyze the rep...
Stroke is a devastating complication of sickle cell anemia (SCA), affecting 5% to 10% of patients before adulthood. Several candidate genetic polymorphisms have been proposed to affect stroke risk, but few have been validated, mainly because previous studies were hampered by relatively small sample sizes and the absence of additional patient cohorts for validation testing. To verify the accurac...
OBJECTIVE Thalassemia is one of the most common genetic disorders worldwide. Cap +1 mutation which causes 'silent beta thalassemia' is present around all ethnic groups of Pakistan. This study was designed to detect the frequency of Cap+1 mutation in Pakistani Population. METHODS Molecular genetic for Cap+1 beta thalassemic mutation was done by extracting DNA from whole blood by using Genomic ...
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