Main results 0.40% of children were exposed to antiepileptic drugs during pregnancy; 0.08% were exposed to valproate. 0.83% of children were diagnosed with autism spectrum disorder during follow-up, including 0.32% with childhood autism. Use of valproate during pregnancy was associated with increased risk for autism spectrum disorder and childhood autism in offspring (Table). Other antiepilepti...

Attention-Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, hyperactivity and/or impulsivity. While ADHD was initially recognized as childhood syndrome, scientific evidence accumulated to indicate that significant proportion of children continue experience symptoms in adulthood. Moreover, the question diagnosis can arise adult patients who were...

OBJECTIVE To examine whether childhood attention-deficit/hyperactivity disorder (ADHD) predicts homelessness in adulthood, and whether the persistence of childhood ADHD through adolescence influences the likelihood of homelessness. METHOD A 33-year prospective, controlled, follow-up was performed of clinic-referred, 6- to 12-year-old boys of white ethnicity with ADHD (probands; mean = 8), at ...

OBJECTIVE We examined long-term outcomes of attention-deficit/hyperactivity disorder (ADHD) in a population-based sample of childhood ADHD cases and controls, prospectively assessed as adults. METHODS Adults with childhood ADHD and non-ADHD controls from the same birth cohort (N = 5718) were invited to participate in a prospective outcome study. Vital status was determined for birth cohort me...

BACKGROUND Although several studies have shown that life adversities play an important role in the etiology and maintenance of both depressive and anxiety disorders, little is known about the relative specificity of several types of life adversities to different forms of depressive and anxiety disorder and the concurrent role of neuroticism. Few studies have investigated whether clustering of l...

OBJECTIVE The aim of this study is to evaluate the association between childhood trauma and the quality of parental bonding in panic disorder compared to non-clinical controls. METHOD 123 patients and 123 paired controls were evaluated with the Mini International Neuropsychiatric Interview, the Childhood Trauma Questionnaire and the Parental Bonding Instrument. RESULTS The Parental Bonding ...

The association between, and stability of, clinical diagnosis and diagnosis derived from the Autism Diagnostic Interview-Revised (ADI-R; Lord, Rutter, & Le Couteur, 1994) was examined in a sample of prospectively identified children with childhood autism and other pervasive developmental disorders assessed at the age of 20 months and 42 months. Clinical diagnosis of autism was stable, with all ...

Objective: To review and reformulate the concept of borderline personality disorder in the light of advances in neuroscience and infant development.Method: Medline was searched using the key words: borderline personality, attachment, affect regulation, neurobiology, childhood sexual abuse, mood stabilizers.Results: There are genetic predispositions to specific personality traits whi...

Background/Aim: Per- and polyfluoroalkyl substances (PFAS) are shown to have neurotoxic effects on animals. Several epidemiological studies reported associations between childhood exposure PFAS neurodevelopment in childhood, but the results remain inconclusive. We examined if concentrations were associated with a diagnosis of autism spectrum disorder (ASD), developmental delay (DD), other early...

Confirmatory factor analysis was used to support the dimensional structure of a four-factor retrospective measure of childhood behavior problems with a large, nonclinical adolescent sample. Acceptable levels of internal consistency and low-to-moderate levels of parent-adolescent interrater agreement were indicated for the four factors of attentional deficit/hyperactivity, oppositional behavior,...