Asthma is an allergic disease characterized by hyperresponsiveness and chronic inflammation of the airway. The interleukin-4 (IL-4) gene and its single nucleotide polymorphisms are associated with asthma susceptibility in children. A case-control study was performed to evaluate the relationship between asthma risk and the IL-4 rs2243250 (589 C/T) and rs2070874 (107 T/C), and IL-4 receptor (IL-4...

OBJECTIVES This study aimed to examine whether a history of asthma from childhood is associated with left ventricular (LV) mass in adulthood. BACKGROUND Asthma has been related to various cardiovascular risk factors affecting LV hypertrophy. The authors saw a need for a prospective study to analyze the relationship between a history of asthma from childhood and markers of LV mass among asympt...

REFERENCES 1 Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. Updated 2011. www.ginasthma.org/ uploads/users/files/GINA_Report2011_May4.pdf 2 Juniper EF, O’Byrne PM, Guyatt GH, et al. Development and validation of a questionnaire to measure asthma control. Eur Respir J 1999; 14: 902–907. 3 Schatz M, Sorkness CA, Li JT, et al. Asthma Control Test: reliability, ...

RATIONALE Virus-induced wheezing episodes in infancy often precede the development of asthma. Whether infections with specific viral pathogens confer differential future asthma risk is incompletely understood. OBJECTIVES To define the relationship between specific viral illnesses and early childhood asthma development. METHODS A total of 259 children were followed prospectively from birth t...

Information on the healthy worker hire effect in relation to asthma is scant. We aimed to assess whether and how childhood asthma-related characteristics (before hire) relate to occupational exposures at first hire. Analyses were conducted in 298 children examined at the first survey of the Epidemiological Study on the Genetics and Environment of Asthma (1991-1995), who reported a training peri...

BACKGROUND Exposure to paracetamol during intrauterine life, childhood, and adult life may increase the risk of developing asthma. We studied 6-7-year-old children from Phase Three of the International Study of Asthma and Allergies in Childhood (ISAAC) programme to investigate the association between paracetamol consumption and asthma. METHODS As part of Phase Three of ISAAC, parents or guard...

background : the international study of asthma and allergies in childhood (isaac) is used to define the prevalence and severity of asthma in different regions. in this study we followed the performance of the isaac video and written questionnaires (vq and wq) to classify asthma in 13-14 yr-old schoolchildren.   methods: the present study was carried out on 3540 school children 13 to 14-yrs-old ...

OBJECTIVES We sought to determine the effects of exposure to environmental tobacco smoke (ETS) and childhood cigarette smoking on asthma symptoms among middle school children in North Carolina. METHODS During 1999-2000, information was collected from a survey completed by the children. Outcomes of asthma symptom reporting were regressed on tobacco smoke exposures. RESULTS Children who curre...

BACKGROUND There is evidence to suggest that the risk of asthma might be increased with exposure to paracetamol in the intrauterine environment, infancy, later childhood and adult life. OBJECTIVE To review the evidence from studies investigating the association between paracetamol use in pregnancy and childhood asthma. METHODS A systematic review and meta-analysis was undertaken of studies ...

Asthma is the most common chronic disease in pediatrics. Most data on the prevalence of childhood allergic diseases come from the International Study of Asthma and Allergies in Childhood (ISAAC) phase II held in 1995 and phase III from 2002. ISAAC created a methodology for studying two age groups 6--7 and 13--14 years old. In 2002, according to the data gathered in the phase III of ISAAC, the p...