Drug resistance is the fundamental reason for tumor recurrence and treatment failure in gynecologic malignant tumors. Drug resistance prevention requires familiarity with physicochemical properties of chemotherapeutic drugs, characteristics of vivo metabolism, correctly chosen chemotherapeutic schemes including multi-drug combination chemotherapy, experimental for doubtful diagnosis and timely ...

It has been suggested that genes that regulate apoptotic cell death may play an important role in determining the sensitivity of tumor cells to chemotherapy. We have recently cloned a member of the bcl-2 family, bcl-x. To test whether bcl-XL expression affects the sensitivity of tumor cells to chemotherapy, we have created stable cell lines overexpressing bcl-XL and have tested these cells for ...

The phenomenon of multidrug resistance implies that a wide spectrum of structurally and functionally unrelated chemotherapeutic drugs are recognized and processed by the molecular system which protects multidrug-resistant (MDR) cells against lipophilic cytotoxic drugs. This suggests that lipophilic agents with low toxicity may also be recognized and processed by this molecular system. At high c...

ATP-binding cassette (ABC) transporters ABCC1 (MRP1), ABCB1 (P-gp), and ABCG2 (BCRP) contribute to chemotherapy failure. The primary goals of this study were to characterize the efficacy and mechanism of the nonsteroidal anti-inflammatory drug (NSAID), sulindac sulfide, to reverse ABCC1 mediated resistance to chemotherapeutic drugs and to determine if sulindac sulfide can influence sensitivity ...

This study investigated the expression of TRAIL and its receptors in human gastric cancer and normal gastric tissues, the effects of rh-TRAIL with or without chemotherapeutic drugs in apoptosis of the gastric cancer cell line SGC7901 and the expression changes of DR4 and DR5 in SGC7901 cells influenced by chemotherapeutic drugs. The expression of TRAIL, DR4 and DcR1 were studied in 34 cases of ...

-In mice with a transplantable mammary carcinoma, treatment with the prostaglandin-synthesis inhibitors flurbiprofen or indomethacin produced various beneficial effects. Survival time after excision of the transplanted tumour was increased, particularly when the drugs were given with the chemotherapeutic agents methrotrexate and melphalan, and there were more disease-free survivors. The combine...

cancer is a group of diseases characterized by uncontrolled proliferation of abnormal cells. because of the severe side effects and resistance to the traditional chemotherapeutic agents, the necessity for discovery of new anticancer drugs is a crucial topic. in the present study we synthesized new derivatives of 2-(4-fluorophenyl)- n -halophenylacetamide and assessed their cytotoxicity against ...

Article Type: Review There are many difficulties and deficiencies in chemotherapeutic drugs especially drug resistances that appear in cancer chemotherapy. In spite of the fact that chemotherapeutic drugs are very effective, severe side effects limit the use of these drugs. People have to pay more attention to natural sources of cancer drugs to increase the anti-cancer agents present in the dru...

A dual stimuli-responsive multi-drug delivery system was developed for "cancer cocktail therapy". Upon UV irradiation, microcapsules could rapidly release the small-molecule drugs, and thereafter the macromolecular drugs would be released in the presence of MMP in the tumor cells. This system will find great potential as a novel chemotherapeutic combination for cancer treatment.

Apoptosis is a kind of programmed cell death that is naturally necessary for homeostasis and some processes like organogenesis and implantation of embryo; so it is not pathologic and harmful all the time. The purpose of this commentary was to describe the ways of stimulating and inhibiting the apoptosis process; because rather in the therapeutic protocols we should stimulate or inhibi...