HYPERCAPNIA, largely through the direct influence of CO2 on proton production, but possibly also via a direct effect of molecular CO2, is the primary chemical stimulus for alveolar ventilation. Small deviations in arterial CO2 in either direction elicit integrated cardiorespiratory reflexes that quickly restore CO2 levels in various tissue and cellular compartments, thereby providing the body w...

The histological, immunocytochemical, and electron microscopic findings in a case of malignant primary pulmonary paraganglioma are reported. The existence of this rare tumour is evidence for the presence of pulmonary chemoreceptors.

Bacterial chemoreceptors of the methyl-accepting chemotaxis protein (MCP) family operate in commingled clusters that enable cells to detect and track environmental chemical gradients with high sensitivity and precision. MCP homodimers of different detection specificities form mixed trimers of dimers that facilitate inter-receptor communication in core signaling complexes, which in turn assemble...

Motile bacteria use large receptor arrays to detect and follow chemical gradients in their environment. Extended receptor arrays, composed of networked signaling complexes, promote cooperative stimulus control of their associated signaling kinases. Here, we used structural lesions at the communication interface between core complexes to create an Escherichia coli strain with functional but disp...