Phase-contrast magnetic resonance imaging is subject to numerous sources of error, which decrease clinical confidence in the reported measures. This work outlines how stationary perivascular fat can impart a significant chemical shift induced phase-contrast magnetic resonance imaging measurement error using computational simulations, in vitro, and in vivo experiments. This chemical shift error ...

Sterically stabilized superparamagnetic iron oxide nanoparticles (SPIONs) were incubated with fresh human erythrocytes (red blood cells [RBCs]) to explore their potential application as magnetic resonance imaging contrast agents. The chemical shift and linewidth of (133)Cs(+) resonances from inside and outside the RBCs in (133)Cs nuclear magnetic resonance spectra were monitored as a function o...

The value of a reduced bandwidth MR imaging technique was tested prospectively in 51 spinal MR examinations by using default (16 kHz) bandwidth, 2000/30, 90 (TR/TEs) and 600/30, and reduced (8 kHz) bandwidth, 2000/48, 92 and 600/30, techniques at 1.5 T. Bandwidth reduction was used to maintain the signal-to-noise ratio for a reduced scan time. Concerns have been raised as to the effect of bandw...

In vivo chemical shift-compensated MR thermometry Pooja Gaur, Beat Werner, Pejman Ghanouni, Rachelle Bitton, Kim Butts Pauly, and William A Grissom Chemical and Physical Biology, Vanderbilt University, Nashville, TN, United States, Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, Center for MR-Research, University Children's Hospital, Zurich, Switzerland, Radio...

Functionalized Multi-walled carbon nanotubes (f-MWCNTs) which are modified using nitric acid and sulfuric acid were evaluated to synthesize a uniform nanocomposite via application of TiO2. The f-MWCNTs-TiO2 nanocomposites have been produced via using the chemical simple two-step method. To characterize the structural analysis, scanning electron microscopy...

The surface chemistry of self-assembled hydrogel fibres - their charge, hydrophobicity and ion-binding dynamics - is recognised to play an important role in determining how the gels develop as well as their suitability for different applications. However, to date there are no established methodologies for the study of this surface chemistry. Here, we demonstrate how solution-state NMR spectrosc...

Introduction: Echo Planar Diffusion weighted imaging is the current method of choice for utilising the diffusion properties of water to localise cancer tumours. While it has had success in distinguishing tumours from tissue it is highly sensitive to patient motion, chemical shift, magnetic susceptibility and phase error build up. We propose the use of HASTE, which is less affected by these arte...

The chemical shift sensitivity and significant signal enhancement afforded by laser-polarized 129Xe have motivated the application of 129Xe NMR to biological imaging and spectroscopy. Recent research done by our group has used laser-polarized 129Xe in biomolecular assays that detect ligand-binding events and distinguish protein conformations. The successful application of unfunctionalized and f...