In pharmaceutical industry ligand based approaches like scaffold hopping, scaffold decoration and me-too approaches, are used to generate lead structures in discovery projects. We use several tools to generate novel lead structures, such as BROOD [1]. BROOD is a software tool which explores chemical space around query molecules based on shape similarity and electrostatics, and it generates anal...

Abstract The main parameters that influence the structure–reactivity relationship of organozinc and organozincate reagents are gathered in this perspective article. Influences substituents, inorganic salts, solvents discussed illustrated with examples from literature. Based on peculiarities chemical system, is enlarged by molecular modelling considerations to raise comprehension at scale struct...

The purpose of this investigation was to develop a simple colorimetric method for creatine kinase (CK). The new method is based on the reaction of creatine, formed enzymatically from creatine phosphate and ADP, with different glyoxal compounds. Hydrated glyoxals, such as para-nitrophenyl, 2-thiophene, 4- biphenyl, 4, 4' -biphenyl,α-naphthyl, β-naphthyl, para-chlorophenyl, and styryl were...

Nanobiotechnology appears to be an emerging science which leads to new developments in the field of medicine. Importance of the magnetic nanomaterials in biomedical science cannot be overlooked. The most commonly used chemical methods to synthesize drugable magnetic nanobeads are co-precipitation, thermal decomposition and microemulsion. However monodispersion, selection of an appropriate coati...

Chemical reactions between certain bis-cyclometalated iridium complexes, cerium(IV) and organic reducing agents in aqueous solution produce an emission of light which in some cases is more intense than that from analogous reactions with conventional ruthenium-based reagents, thus providing a new avenue for chemically-initiated luminescence detection.