Cholestatic liver injury is frequently associated with drug inhibition of bile salt transporters, such as the export pump (BSEP). Reliable in silico models to predict BSEP directly from chemical structures would significantly reduce costs during discovery and could help avoid patients. We report our development classification regression for substantially improved performance over previously pub...

Single Nucleotide Polymorphisms (SNPs) are the most usual form of polymorphism in human genome.Analyses of genetic variations have revealed that individual genomes share common SNP-haplotypes. Theparticular pattern of these common variations forms a block-like structure on human genome. In this work,we develop a new method based on the Perfect Phylogeny Model to identify haplo...

this study investigated intra-specific variation in the growth parameters and dry mat-ter partitioning of sugar beet cultivars at different levels of salinity (0, 50, 150, 250 and 350 mm nacl + cacl2 in 5:1 molar ratio) using four cvs, one british (madison) and three iranian cvs (7233-p12, 7233-p21 and 7233-p29). the plants were grown in a controlled greenhouse environment for about 18 weeks. a...

Hematoporphyrin is being used as a photosensitizer in photodynamic therapy of tumors, as well as of other clinical cases. Many classes of tetrapyrroles, including hematoporphyrin, are partitioning quite easily into the external cytoplasmic membrane as the mechanism of cellular uptake. Several chemical and physical parameters of the membrane were studied for their effect on the extent of porphyr...

We use the chemical transport model GEOS-Chem to evaluate the hypothesis that atmospheric polycyclic aromatic hydrocarbons (PAHs) are trapped in secondary organic aerosol (SOA) as it forms. We test the ability of three different partitioning configurations within the model to reproduce observed total concentrations in the midlatitudes and the Arctic as well as midlatitude gas-particle phase dis...

The purpose of this study was to collect experimental data and develop a mathematical model describing the equilibrium phase distribution of a common organic chemical, trichloroethylene (TCE), among cyclodextrin (CD), water, and granular-activated carbon (GAC). Batch tests and a modified linear regression model were applied to assess the partitioning behavior in this multiphase (CD pseudophase–...